Document Detail

Induction and emergence in infants less than 60 weeks post-conceptual age: comparison of thiopental, halothane, sevoflurane and desflurane.
MedLine Citation:
PMID:  9640149     Owner:  NLM     Status:  MEDLINE    
We have studied 40 infants with a post-conceptual age of less than 60 weeks undergoing general anaesthesia for herniotomy. Patients were anaesthetized with 1 MAC equivalent values for age and agent and allocated randomly to receive halothane, savoflurane or thiopental for induction, and halothane, sevoflurane or desflurane for maintenance of anaesthesia. At induction, both time to acceptance of a face mask and loss of eyelash reflex were recorded. Emergence times were noted by a blinded observer. Induction and emergence times were similar between the halothane and sevoflurane groups but were consistently shorter in the desflurane group compared with the halothane or sevoflurane groups. There were no problems at extubation or significant apnoea in any group. Induction of anaesthesia in this population was no quicker with sevoflurane than with halothane and the method used for induction did not influence recovery time. Maintenance of anaesthesia with desflurane resulted in a shorter recovery time in infants in whom anaesthesia was induced with halothane or thiopental. Desflurane maintenance may be particularly beneficial in the neonate.
K O'Brien; D N Robinson; N S Morton
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  British journal of anaesthesia     Volume:  80     ISSN:  0007-0912     ISO Abbreviation:  Br J Anaesth     Publication Date:  1998 Apr 
Date Detail:
Created Date:  1998-07-06     Completed Date:  1998-07-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372541     Medline TA:  Br J Anaesth     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  456-9     Citation Subset:  IM    
Department of Anaesthesia, Royal Hospital for Sick Children, Yorkhill NHS Trust, Glasgow.
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MeSH Terms
Anesthesia Recovery Period
Anesthetics, Combined
Anesthetics, Inhalation* / adverse effects
Anesthetics, Intravenous*
Hernia, Inguinal / surgery
Isoflurane / analogs & derivatives
Methyl Ethers
Postoperative Complications / chemically induced
Respiration Disorders / chemically induced
Single-Blind Method
Reg. No./Substance:
0/Anesthetics, Combined; 0/Anesthetics, Inhalation; 0/Anesthetics, Intravenous; 0/Methyl Ethers; 151-67-7/Halothane; 26675-46-7/Isoflurane; 28523-86-6/sevoflurane; 57041-67-5/desflurane; 76-75-5/Thiopental

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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