Document Detail

Induction of Müllerian duct derivatives in testicular feminized (Tfm) mice by prenatal exposure to diethylstilbestrol.
MedLine Citation:
PMID:  6721219     Owner:  NLM     Status:  MEDLINE    
When pregnant mice carrying the Tfm mutation gene were injected with diethylstilbestrol (DES) from Days 9 to 16 of gestation, the regression of the Müllerian duct derivatives was inhibited in their wild male and Tfm male offspring. The degree of persistence of the Müllerian duct derivatives demonstrated a dependence on DES dose. Complete or almost complete preservation of the Müllerian ducts was observed in the animals exposed to high doses of DES. Since Tfm males from non-injected mothers had no reproductive tract except the vaginal anlage, despite the presence of testes, bilateral occurrence of the Müllerian duct derivatives in Tfm males following prenatal exposure to DES indicates that the characteristic features of the reproductive tract in these animals are almost the same as that in normal females.
S Kobayashi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Anatomy and embryology     Volume:  169     ISSN:  0340-2061     ISO Abbreviation:  Anat. Embryol.     Publication Date:  1984  
Date Detail:
Created Date:  1984-06-19     Completed Date:  1984-06-19     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7505194     Medline TA:  Anat Embryol (Berl)     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  35-9     Citation Subset:  IM    
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MeSH Terms
Androgen-Insensitivity Syndrome / pathology*
Diethylstilbestrol / pharmacology*
Dose-Response Relationship, Drug
Mice, Mutant Strains
Mullerian Ducts / drug effects*
Time Factors
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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