| Induction of a distinct nuclear poly(A) polymerase and the production of anti-tumor poly(A) polymerase antibodies in hepatocarcinogenesis. | |
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MedLine Citation:
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PMID: 6091938 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Primary hepatomas induced in rats by an azo dye contained a distinct nuclear poly(A) polymerase which was different from the corresponding normal liver enzyme with respect to molecular weight and peptide map. The two enzymes could also be distinguished by their immunological characteristics. Sera from the carcinogen-fed rats contained antibodies to the tumor poly(A) polymerase even before the appearance of neoplastic nodules. |
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Authors:
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D A Stetler; L E Wrenshall; Y Park; S T Jacob |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Carcinogenesis Volume: 5 ISSN: 0143-3334 ISO Abbreviation: Carcinogenesis Publication Date: 1984 Oct |
Date Detail:
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Created Date: 1984-11-28 Completed Date: 1984-11-28 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8008055 Medline TA: Carcinogenesis Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1363-6 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antibodies / analysis* Cell Nucleus / enzymology* Enzyme Induction Liver / enzymology* Liver Neoplasms, Experimental / chemically induced, enzymology*, immunology Male Nucleotidyltransferases / biosynthesis* Polynucleotide Adenylyltransferase / biosynthesis*, immunology Rats Rats, Inbred F344 |
| Grant Support | |
ID/Acronym/Agency:
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CA 25078/CA/NCI NIH HHS; CA 31894/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antibodies; EC 2.7.7.-/Nucleotidyltransferases; EC 2.7.7.19/Polynucleotide Adenylyltransferase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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