Document Detail


Induction of differentiation of human and mouse myeloid leukemia cells by camptothecin.
MedLine Citation:
PMID:  2302199     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Low concentrations of camptothecin induced differentiation of human and mouse myeloid leukemia cells including human HL60, U937, ML1, and K562 cells and mouse M1 cells as measured by various differentiation-associated properties. When K562 cells were pretreated with 20 nM camptothecin for 2 h, 53% of the cells were induced to differentiate as measured by NBT staining. Significant single strand breaks in DNA of K562 cells were caused by this treatment. Most single strand breaks were accompanied by protein-DNA cross linking. The combination of camptothecin and rTNF synergistically induced differentiation of human ML1, U937, and M1 cells. These results suggest that topo I may be important in some differentiation of myeloid leukemia cells.
Authors:
S Chou; M Kaneko; K Nakaya; Y Nakamura
Related Documents :
3862669 - Amiloride in differentiation and commitment of friend erythroleukemia cells.
9874489 - Dendritic cells enhance the differentiation of naïve b cells into plasma cells in vitro.
2137129 - Role of lipocortin i in the glucocorticoid induction of the terminal differentiation of...
15175249 - Homotypic signalling regulates gata1 activity in the erythroblastic island.
21360439 - The primary cilium: a relevant characteristic in interstitial cells of rat duodenum ent...
15271799 - G6pd is indispensable for erythropoiesis after the embryonic-adult hemoglobin switch.
21600879 - Asperlin induces g₂/m arrest through ros generation and atm pathway in human cervical...
8881519 - Pre-treatment with trimetazidine increases sarcolemmal mechanical resistance in reoxyge...
8414909 - Effect of short-chain fatty acids on cell volume and intracellular ph in rat distal colon.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  166     ISSN:  0006-291X     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  1990 Jan 
Date Detail:
Created Date:  1990-02-28     Completed Date:  1990-02-28     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  160-7     Citation Subset:  IM    
Affiliation:
School of Pharmaceutical Sciences, Showa University, Tokyo, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Biological Markers / analysis
Camptothecin / pharmacology*
Cell Differentiation / drug effects
Cell Line
Humans
Kinetics
Leukemia
Leukemia, Experimental
Mice
Phagocytosis
Receptors, Fc / analysis
Time Factors
Tumor Cells, Cultured / cytology,  drug effects*,  physiology
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Receptors, Fc; 7689-03-4/Camptothecin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Purification and measurement of calpromotin, the cytoplasmic protein which activates calcium-depende...
Next Document:  The brain-type glucose transporter mRNA is specifically expressed at the blood-brain barrier.