Document Detail

Induction of differentiation of human and mouse myeloid leukemia cells by camptothecin.
MedLine Citation:
PMID:  2302199     Owner:  NLM     Status:  MEDLINE    
Low concentrations of camptothecin induced differentiation of human and mouse myeloid leukemia cells including human HL60, U937, ML1, and K562 cells and mouse M1 cells as measured by various differentiation-associated properties. When K562 cells were pretreated with 20 nM camptothecin for 2 h, 53% of the cells were induced to differentiate as measured by NBT staining. Significant single strand breaks in DNA of K562 cells were caused by this treatment. Most single strand breaks were accompanied by protein-DNA cross linking. The combination of camptothecin and rTNF synergistically induced differentiation of human ML1, U937, and M1 cells. These results suggest that topo I may be important in some differentiation of myeloid leukemia cells.
S Chou; M Kaneko; K Nakaya; Y Nakamura
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  166     ISSN:  0006-291X     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  1990 Jan 
Date Detail:
Created Date:  1990-02-28     Completed Date:  1990-02-28     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  160-7     Citation Subset:  IM    
School of Pharmaceutical Sciences, Showa University, Tokyo, Japan.
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MeSH Terms
Biological Markers / analysis
Camptothecin / pharmacology*
Cell Differentiation / drug effects
Cell Line
Leukemia, Experimental
Receptors, Fc / analysis
Time Factors
Tumor Cells, Cultured / cytology,  drug effects*,  physiology
Reg. No./Substance:
0/Biological Markers; 0/Receptors, Fc; 7689-03-4/Camptothecin

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