Document Detail

Induction of cytochrome P-450c in hematopoietic cells of fetal liver.
MedLine Citation:
PMID:  3541928     Owner:  NLM     Status:  MEDLINE    
The transplacental inductive effect of beta-naphthoflavone (beta NF) on cytochrome P-450 isozymes was studied in separate hematopoietic and hepatocyte cells from fetal rat liver. Two fractions of dispersed fetal liver cells were isolated by Ficoll-Paque centrifugation and shown by histologic examination to be enriched in erythroblasts and hepatocytes, respectively. beta NF treatment increased ethoxyresorufin-O-deethylase activity 250-fold in both erythroblast and hepatocyte cell fractions. Polyacrylamide gel electrophoresis and immunostaining techniques showed the induction of cytochrome P-450c, but not P-450d, in erythroblast and hepatocyte fractions.
K T Shiverick; A G Kvello-Stenstrom; W H Donnelly; A S Salhab; J A Goldstein; M O James
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  141     ISSN:  0006-291X     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  1986 Nov 
Date Detail:
Created Date:  1987-02-04     Completed Date:  1987-02-04     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  299-305     Citation Subset:  IM    
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MeSH Terms
Benzoflavones / pharmacology
Cell Separation
Cytochrome P-450 CYP1A1
Cytochrome P-450 Enzyme System / biosynthesis*,  immunology
Enzyme Induction / drug effects
Hematopoietic Stem Cells / enzymology*
Immunosorbent Techniques
Liver / cytology,  embryology*,  enzymology
Microsomes, Liver / enzymology*
Oxidoreductases / metabolism
Grant Support
Reg. No./Substance:
0/Benzoflavones; 6051-87-2/beta-Naphthoflavone; 9035-51-2/Cytochrome P-450 Enzyme System; EC 1.-/Oxidoreductases; EC P-450 CYP1A1

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