Document Detail

Induction of coronary artery spasm by acetylcholine in patients with variant angina: possible role of the parasympathetic nervous system in the pathogenesis of coronary artery spasm.
MedLine Citation:
PMID:  3769179     Owner:  NLM     Status:  MEDLINE    
We injected acetylcholine (ACh), the neurotransmitter of the parasympathetic nervous system, into the coronary arteries of 28 patients with variant angina. Injection of 10 to 80 micrograms ACh into the coronary artery responsible for the attack induced spasm together with chest pain and ST segment elevation or depression on the electrocardiogram in 30 of the 32 arteries of the 25 of the 27 patients. The injection of 20 to 100 micrograms ACh into the coronary artery not responsible for the attack in 18 patients resulted in various degrees of constriction in most of them, but no spasm in any of them. After intravenous injection of 1.0 to 1.5 mg atropine sulfate, the injection of ACh into the coronary artery responsible for the attack did not induce spasm or attack in any of the nine coronary arteries injected in eight patients. We conclude that the intracoronary injection of ACh induces coronary spasm and attack in patients with variant angina and that the activity of the parasympathetic nervous system may play a role in the pathogenesis of coronary spasm. We also conclude that the intracoronary injection of ACh is a useful test for provocation of coronary spasm.
H Yasue; Y Horio; N Nakamura; H Fujii; N Imoto; R Sonoda; K Kugiyama; K Obata; Y Morikami; T Kimura
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Circulation     Volume:  74     ISSN:  0009-7322     ISO Abbreviation:  Circulation     Publication Date:  1986 Nov 
Date Detail:
Created Date:  1986-11-24     Completed Date:  1986-11-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  955-63     Citation Subset:  AIM; IM    
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MeSH Terms
Acetylcholine / administration & dosage,  diagnostic use,  pharmacology*
Angina Pectoris, Variant / physiopathology*
Atropine / administration & dosage,  pharmacology
Coronary Angiography
Coronary Vasospasm / diagnosis,  etiology*,  radiography
Injections, Intravenous
Middle Aged
Parasympathetic Nervous System / physiopathology*
Reg. No./Substance:
51-55-8/Atropine; 51-84-3/Acetylcholine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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