| Induction of complete and sustained remission of rheumatoid pachymeningitis by rituximab. | |
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MedLine Citation:
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PMID: 19479865 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Aseptic pachymeningitis is a rare and serious complication of rheumatoid arthritis (RA). Herein, we describe a patient with rheumatoid factor-positive and anti-cyclic citrullinated peptide-positive RA who experienced a focal seizure, with aphasia and convulsions of the right side of the body. The findings of magnetic resonance imaging and histologic analysis led to a diagnosis of rheumatoid pachymeningitis. Because the patient had a large number of CD20-expressing B lymphocytes, therapy with rituximab was started and has resulted in complete and sustained remission of both the pachymeningitis and the RA for >2 years. Despite a decrease in immunoglobulins, the patient has remained free of infections, which illustrates the favorable outcome that can result from therapeutic B cell depletion in this potentially lethal manifestation of RA. |
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Authors:
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L Schmid; M Müller; T Treumann; W Arnold; B Möller; D Aeberli; P M Villiger |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Arthritis and rheumatism Volume: 60 ISSN: 0004-3591 ISO Abbreviation: Arthritis Rheum. Publication Date: 2009 Jun |
Date Detail:
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Created Date: 2009-06-16 Completed Date: 2009-08-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370605 Medline TA: Arthritis Rheum Country: United States |
Other Details:
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Languages: eng Pagination: 1632-4 Citation Subset: AIM; IM |
Affiliation:
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Kantonsspital, Lucerne, Switzerland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antibodies, Monoclonal
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therapeutic use* Antigens, CD20 / metabolism Antirheumatic Agents / therapeutic use* Arthritis, Rheumatoid / complications*, drug therapy* B-Lymphocytes / immunology Humans Magnetic Resonance Imaging Male Meningitis / diagnosis, drug therapy*, etiology* Middle Aged Remission Induction Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Monoclonal; 0/Antigens, CD20; 0/Antirheumatic Agents; 0/rituximab |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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