| Induction chemotherapy in locally advanced pharyngolaryngeal cancers with stridor: is it feasible and safe? | |
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MedLine Citation:
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PMID: 22924129 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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Background. The standard initial management of patients with locally advanced pharyngolaryngeal presenting with stridor is tracheostomy. Tracheostomy has been shown to negatively impact cancer-related outcomes. Methods. Retrospective analysis of prospectively collected data of 9 patients, who underwent induction chemotherapy with the aim of prevention of tracheostomy. Presenting features, time to resolution of stridor, and further management are reported. Results. Eight out of 9 patient received chemotherapy within 12 hours of presentation with stridor. There were 4 patients each with primary hypopharynx and larynx. The stage was IVA in 6 patients and IVB in 2 patients. In all patients receiving immediate chemotherapy, clinical stridor resolved within 48 hours. The radiological response rate was 62.5%. The median reduction in size of tumor was 37%. Conclusion. Immediate neoadjuvant chemotherapy is a feasible and safe option for patients presenting with early stridor and helps in resolution of stridor and avoiding tracheostomy. |
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Authors:
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Vijay Maruti Patil; Vanita Noronha; Amit Joshi; Vamshi Muddu; Bhavesh Poladia; Bharat Chauhan; Kumar Prabhash; Devendra Arvind Chaukar; Pankaj Chatturvedi; Gouri Pantvaidya; Shashikant Juvekar; Anil D'cruz |
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Publication Detail:
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Type: Journal Article Date: 2012-08-12 |
Journal Detail:
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Title: Chemotherapy research and practice Volume: 2012 ISSN: 2090-2115 ISO Abbreviation: Chemother Res Pract Publication Date: 2012 |
Date Detail:
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Created Date: 2012-08-27 Completed Date: 2012-09-12 Revised Date: 2013-03-14 |
Medline Journal Info:
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Nlm Unique ID: 101566606 Medline TA: Chemother Res Pract Country: Egypt |
Other Details:
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Languages: eng Pagination: 549170 Citation Subset: - |
Affiliation:
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Department of Medical Oncology, Tata Memorial Hospital, Mumbai 400012, India. |
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