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Induction chemotherapy in locally advanced pharyngolaryngeal cancers with stridor: is it feasible and safe?
MedLine Citation:
PMID:  22924129     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Background. The standard initial management of patients with locally advanced pharyngolaryngeal presenting with stridor is tracheostomy. Tracheostomy has been shown to negatively impact cancer-related outcomes. Methods. Retrospective analysis of prospectively collected data of 9 patients, who underwent induction chemotherapy with the aim of prevention of tracheostomy. Presenting features, time to resolution of stridor, and further management are reported. Results. Eight out of 9 patient received chemotherapy within 12 hours of presentation with stridor. There were 4 patients each with primary hypopharynx and larynx. The stage was IVA in 6 patients and IVB in 2 patients. In all patients receiving immediate chemotherapy, clinical stridor resolved within 48 hours. The radiological response rate was 62.5%. The median reduction in size of tumor was 37%. Conclusion. Immediate neoadjuvant chemotherapy is a feasible and safe option for patients presenting with early stridor and helps in resolution of stridor and avoiding tracheostomy.
Authors:
Vijay Maruti Patil; Vanita Noronha; Amit Joshi; Vamshi Muddu; Bhavesh Poladia; Bharat Chauhan; Kumar Prabhash; Devendra Arvind Chaukar; Pankaj Chatturvedi; Gouri Pantvaidya; Shashikant Juvekar; Anil D'cruz
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Publication Detail:
Type:  Journal Article     Date:  2012-08-12
Journal Detail:
Title:  Chemotherapy research and practice     Volume:  2012     ISSN:  2090-2115     ISO Abbreviation:  Chemother Res Pract     Publication Date:  2012  
Date Detail:
Created Date:  2012-08-27     Completed Date:  2012-09-12     Revised Date:  2013-03-14    
Medline Journal Info:
Nlm Unique ID:  101566606     Medline TA:  Chemother Res Pract     Country:  Egypt    
Other Details:
Languages:  eng     Pagination:  549170     Citation Subset:  -    
Affiliation:
Department of Medical Oncology, Tata Memorial Hospital, Mumbai 400012, India.
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