Document Detail


Induction of cell infiltration and acid hydrolase release into the peritoneal cavity of mice.
MedLine Citation:
PMID:  7390619     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
An injection of thioglycollate into the peritoneal cavity of mice produced a peak of exudate at 4 h, a peak of total leukocytes at 24 h when the predominant cell was the polymorphonuclear neutrophil, and a secondard macrophage phase beginning 2--3 days after thioglycollate. The release of N-acetylglucosaminidase (EC 3.2.1.30) into the peritoneal fluid paralleled the macrophage phase. The amount of enzyme released was related to the dose of thioglycollate. Neither zymosan (400 micrograms) nor endotoxin (30 micrograms) produced a marked inflammatory response when injected into the peritoneal cavity.
Authors:
A P Green; F Mangan; J E Ormerod
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Inflammation     Volume:  4     ISSN:  0360-3997     ISO Abbreviation:  Inflammation     Publication Date:  1980 Jun 
Date Detail:
Created Date:  1980-09-28     Completed Date:  1980-09-28     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7600105     Medline TA:  Inflammation     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  205-13     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Acetylglucosaminidase / metabolism*
Animals
Cell Differentiation / drug effects
Cell Movement / drug effects
Endotoxins / pharmacology
Female
Hexosaminidases / metabolism*
Lysosomes / enzymology
Mice
Neutrophils / drug effects
Peritoneal Cavity / cytology*,  enzymology
Thioglycolates / pharmacology
Time Factors
Zymosan / pharmacology
Chemical
Reg. No./Substance:
0/Endotoxins; 0/Thioglycolates; 9010-72-4/Zymosan; EC 3.2.1.-/Hexosaminidases; EC 3.2.1.52/Acetylglucosaminidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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