| Induction of calcium release from sarcoplasmic reticulum of skeletal muscle by xanthone and norathyriol. | |
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MedLine Citation:
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PMID: 8842439 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1. Effects of xanthone and its derivative, 1,3,6,7-tetrahydroxyxanthone (norathyriol), on Ca2+ release and ryanodine binding were studied in isolated sarcoplasmic reticulum (SR) vesicles from rabbit skeletal muscle. 2. Both xanthone and norathyriol dose-dependently induced Ca2+ release from the actively loaded SR vesicles which was blocked by ruthenium red, a specific Ca2+ release inhibitor, and Mg2+. 3. Xanthone and norathyriol also dose-dependently increased apparent [3H]-ryanodine binding. Norathyriol, but not xanthone, produced a synergistic effect on binding activation when added concurrently with caffeine. 4. In the presence of Mg2+, which inhibits ryanodine binding, both caffeine and norathyriol, but not xanthone, could restore the binding to the level observed in the absence of Mg2+. 5. Xanthone activated the Ca(2+)-ATPase activity of isolated SR vesicles dose-dependently reaching 70% activation at 300 microM. 6. When tested in mouse diaphragm, norathyriol potentiated the muscle contraction followed by twitch depression and contracture in either a Ca(2+) -free bathing solution or one containing 2.5 mM Ca2+. These norathyriol-induced effects on muscle were inhibited by pretreatment with ruthenium red or ryanodine. 7. These data suggest that xanthone and norathyriol can induce Ca2+ release from the SR of skeletal muscle through a direct interaction with the Ca2+ release channel, also known as the ryanodine receptor. |
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Authors:
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J J Kang; Y W Cheng; F N Ko; M L Kuo; C N Lin; C M Teng |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: British journal of pharmacology Volume: 118 ISSN: 0007-1188 ISO Abbreviation: Br. J. Pharmacol. Publication Date: 1996 Aug |
Date Detail:
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Created Date: 1997-01-29 Completed Date: 1997-01-29 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 7502536 Medline TA: Br J Pharmacol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1736-42 Citation Subset: IM |
Affiliation:
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Institute of Toxicology, College of Medicine, National Taiwan University, Taipei, R.O.C. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Caffeine / pharmacology Calcium / metabolism* Calcium Channels / drug effects, metabolism Calcium-Transporting ATPases / metabolism Diaphragm / drug effects Female Magnesium / pharmacology Male Mice Mice, Inbred ICR Muscle Contraction / drug effects Muscle Proteins / metabolism Muscle, Skeletal / drug effects, enzymology, metabolism* Phosphodiesterase Inhibitors / pharmacology Potassium Chloride / pharmacology Rabbits Ruthenium Red / pharmacology Ryanodine / metabolism Sarcoplasmic Reticulum / enzymology, metabolism* Xanthenes / antagonists & inhibitors, pharmacology* Xanthones* |
| Chemical | |
Reg. No./Substance:
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0/Calcium Channels; 0/Muscle Proteins; 0/Phosphodiesterase Inhibitors; 0/Xanthenes; 0/Xanthones; 11103-72-3/Ruthenium Red; 15662-33-6/Ryanodine; 3542-72-1/norathyriol; 58-08-2/Caffeine; 7439-95-4/Magnesium; 7440-70-2/Calcium; 7447-40-7/Potassium Chloride; 90-47-1/xanthone; EC 3.6.1.8/Calcium-Transporting ATPases |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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