Document Detail

Induction of c-fos, junB, c-jun, and hsp70 mRNA in cortex, thalamus, basal ganglia, and hippocampus following middle cerebral artery occlusion.
MedLine Citation:
PMID:  8063876     Owner:  NLM     Status:  MEDLINE    
Middle cerebral artery (MCA) occlusion in halothane-anesthetized rats induced c-fos, junB, and c-jun immediate early gene mRNAs and hsp70 heat shock gene mRNA in brain. In situ hybridization studies showed that c-fos and junB were induced throughout all of the cortex at 1 and 4 h following MCA occlusion. hsp70 was induced in the core and margins of the MCA ischemia. By 24 h, there was little expression of c-fos, junB, c-jun, and hsp70 in the core of the MCA infarct; there was modest induction of hsp70 at the margins of the infarct; and there was diffuse induction of c-fos, junB, and c-jun in all of the cortex outside the infarct. MCA occlusion also induced these genes in subcortical structures. c-fos, junB, and hsp70 were induced in ipsilateral medial striatum, most of thalamus including medial and lateral geniculate nuclei, substantia nigra, and hippocampus. Most of these structures, except for the striatum, are not supplied by the MCA. These data show that changes in gene expression can occur in regions remote from an infarction.
H Kinouchi; F R Sharp; P H Chan; J Koistinaho; S M Sagar; T Yoshimoto
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism     Volume:  14     ISSN:  0271-678X     ISO Abbreviation:  J. Cereb. Blood Flow Metab.     Publication Date:  1994 Sep 
Date Detail:
Created Date:  1994-09-20     Completed Date:  1994-09-20     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8112566     Medline TA:  J Cereb Blood Flow Metab     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  808-17     Citation Subset:  IM    
Division of Neurosurgery, Tohoku University School of Medicine, Sendai, Japan.
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MeSH Terms
Arterial Occlusive Diseases / genetics,  metabolism*
Brain Chemistry / genetics*
Cerebral Arterial Diseases / genetics,  metabolism*
Gene Expression Regulation / physiology
Genes, Immediate-Early*
Genes, fos
Genes, jun
Heat-Shock Proteins / genetics*
In Situ Hybridization
RNA, Messenger / biosynthesis*
Rats, Sprague-Dawley
Reg. No./Substance:
0/Heat-Shock Proteins; 0/RNA, Messenger

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