Document Detail

Induction of c-Jun mRNA without changes of estrogen and progesterone receptor expression in myometrium during human labor.
Jump to Full Text
MedLine Citation:
PMID:  10576152     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To elucidate the endocrine mechanism of human parturition, the expression of c-Jun and c-Fos mRNA were examined in relation to estrogen receptor (ER) and progesterone receptor (PR) in human myometrium. c-Jun mRNA was detected in all myometrial tissues (n=5) during labor but not before labor (n=5) and in oxytocin-resistant postterm pregnancy (n=3). c-Fos mRNA was detected in only one myometrial tissue from a woman in labor. The distribution and intensity of immunostaining for ER and PR were semiquantitatively scored. During the late pregnancies, no significant difference was seen in the receptor scores for myometrial ER and PR between the patients who experienced labor and those who did not. Receptor scores for ER and PR were significantly lower in postterm pregnancy than in late pregnancy, regardless of the labor status. These data suggest that there are no changes in ER and PR in human myometrium during parturition. On the other hand, postterm pregnancy is associated with low ER and PR. c-Jun, induced during labor without changes in ER and PR, may play a role as a signaling mechanism in human myometrium.
Authors:
C R Roh; B L Lee; W J Oh; J D Whang; D S Choi; B K Yoon; J H Lee
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of Korean medical science     Volume:  14     ISSN:  1011-8934     ISO Abbreviation:  J. Korean Med. Sci.     Publication Date:  1999 Oct 
Date Detail:
Created Date:  2000-01-24     Completed Date:  2000-01-24     Revised Date:  2011-03-16    
Medline Journal Info:
Nlm Unique ID:  8703518     Medline TA:  J Korean Med Sci     Country:  KOREA (SOUTH)    
Other Details:
Languages:  eng     Pagination:  552-8     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology, Sungkyunkwan University School of Medicine, Seoul, Korea. crroh@smc.samsung.co.kr
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Blotting, Northern
Female
Genes, jun / genetics*
Humans
Immunohistochemistry
Labor, Obstetric / metabolism*
Myometrium / cytology,  metabolism*
Pregnancy
RNA, Messenger / analysis
Receptors, Estrogen / metabolism*
Receptors, Progesterone / metabolism*
Reference Values
Chemical
Reg. No./Substance:
0/RNA, Messenger; 0/Receptors, Estrogen; 0/Receptors, Progesterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Full Text
Journal Information
Journal ID (nlm-ta): J Korean Med Sci
Journal ID (pmc): jkms
ISSN: 1011-8934
ISSN: 1598-6357
Publisher: Korean Academy of Medical Sciences
Article Information
Download PDF

Print publication date: Month: 10 Year: 1999
Volume: 14 Issue: 5
First Page: 552 Last Page: 558
ID: 3054461
PubMed Id: 10576152

Induction of c-Jun mRNA without changes of estrogen and progesterone receptor expression in myometrium during human labor.
C. R. Roh Email: crroh@smc.samsung.co.kr
B. L. Lee
W. J. Oh
J. D. Whang
D. S. Choi
B. K. Yoon
J. H. Lee
Department of Obstetrics and Gynecology, Sungkyunkwan University School of Medicine, Seoul, Korea.


Article Categories:
  • Research Article


Previous Document:  The relationship between plasma leptin and nutritional status in chronic hemodialysis patients.
Next Document:  Chondroblastoma of the temporal bone: a clinicopathologic study of five cases.