| Induction of autophagy is essential for monocyte-macrophage differentiation. | |
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MedLine Citation:
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PMID: 22223827 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Monocytes are programmed to undergo apoptosis in the absence of stimulation. Stimuli that promote monocyte-macrophage differentiation not only cause cellular changes but also prevent the default apoptosis of monocytes. Here we demonstrate that autophagy is induced when monocytes are triggered to differentiate and that the induction of autophagy is pivotal for the survival and differentiation of monocytes. We show that inhibition of autophagy results in the apoptosis of cells that are engaged in differentiation. We find that the differentiation signal releases Beclin1 from Bcl-2 through activating JNK and blocks Atg5 cleavage, both events are critical to the induction of autophagy. Importantly, preventing autophagy induction hampers differentiation and cytokine production. Thus, autophagy is an important transition from monocyte apoptosis to differentiation. |
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Authors:
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Yan Zhang; Michael J Morgan; Kun Chen; Swati Choksi; Zheng-Gang Liu |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-5 |
Journal Detail:
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Title: Blood Volume: - ISSN: 1528-0020 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-6 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7603509 Medline TA: Blood Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Cell and Cancer Biology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States; |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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