| Induction of atrial depolarization abnormality during dipyridamole stress imaging: a cautionary note. | |
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MedLine Citation:
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PMID: 17934267 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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P-wave widening on the 12-lead electrocardiogram denotes abnormal atrial depolarization and has been shown to be associated with myocardial ischemia during treadmill exercise tolerance testing. However, its true significance during dipyridamole (Persantine) stress imaging remains questionable given the potential direct as well as indirect effects of dipyridamole on the atria. We present a novel series of 5 comparable cases of dipyridamole stress imaging where serial P-wave duration increase occurred during administration of dipyridamole. We observed that such P-wave widening occurred even in the absence of evidence of myocardial ischemia on subsequent myocardial perfusion imaging. Clinicians should therefore be aware of this potential association where, unlike that observed with graded exercise treadmill testing, P-wave widening during dipyridamole infusion could perhaps be a pharmacological effect on the atria instead of an indication of underlying myocardial ischemia. |
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Authors:
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Laxman Prajapat; Vignendra Ariyarajah; David H Spodick |
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Publication Detail:
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Type: Journal Article Date: 2007-10-10 |
Journal Detail:
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Title: Cardiology Volume: 110 ISSN: 1421-9751 ISO Abbreviation: Cardiology Publication Date: 2008 |
Date Detail:
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Created Date: 2008-04-02 Completed Date: 2008-04-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 1266406 Medline TA: Cardiology Country: Switzerland |
Other Details:
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Languages: eng Pagination: 35-8 Citation Subset: IM |
Affiliation:
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Department of Medicine, Saint Vincent Hospital, University of Massachusetts, Worcester, Mass., USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Chest Pain / diagnosis* Dipyridamole / adverse effects*, diagnostic use Electrocardiography* Exercise Test / adverse effects*, methods Follow-Up Studies Heart Atria / physiopathology Humans Male Myocardial Ischemia / diagnosis, etiology* Risk Assessment Safety Management Sampling Studies |
| Chemical | |
Reg. No./Substance:
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58-32-2/Dipyridamole |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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