Document Detail

Induction of atrial depolarization abnormality during dipyridamole stress imaging: a cautionary note.
MedLine Citation:
PMID:  17934267     Owner:  NLM     Status:  MEDLINE    
P-wave widening on the 12-lead electrocardiogram denotes abnormal atrial depolarization and has been shown to be associated with myocardial ischemia during treadmill exercise tolerance testing. However, its true significance during dipyridamole (Persantine) stress imaging remains questionable given the potential direct as well as indirect effects of dipyridamole on the atria. We present a novel series of 5 comparable cases of dipyridamole stress imaging where serial P-wave duration increase occurred during administration of dipyridamole. We observed that such P-wave widening occurred even in the absence of evidence of myocardial ischemia on subsequent myocardial perfusion imaging. Clinicians should therefore be aware of this potential association where, unlike that observed with graded exercise treadmill testing, P-wave widening during dipyridamole infusion could perhaps be a pharmacological effect on the atria instead of an indication of underlying myocardial ischemia.
Laxman Prajapat; Vignendra Ariyarajah; David H Spodick
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Publication Detail:
Type:  Journal Article     Date:  2007-10-10
Journal Detail:
Title:  Cardiology     Volume:  110     ISSN:  1421-9751     ISO Abbreviation:  Cardiology     Publication Date:  2008  
Date Detail:
Created Date:  2008-04-02     Completed Date:  2008-04-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1266406     Medline TA:  Cardiology     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  35-8     Citation Subset:  IM    
Department of Medicine, Saint Vincent Hospital, University of Massachusetts, Worcester, Mass., USA.
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MeSH Terms
Chest Pain / diagnosis*
Dipyridamole / adverse effects*,  diagnostic use
Exercise Test / adverse effects*,  methods
Follow-Up Studies
Heart Atria / physiopathology
Myocardial Ischemia / diagnosis,  etiology*
Risk Assessment
Safety Management
Sampling Studies
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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