Document Detail

Induction at high frequency of a unique phenotypic class of Bacillus subtilis mutants by methylxanthines.
MedLine Citation:
PMID:  6403857     Owner:  NLM     Status:  MEDLINE    
Caffeine and theophylline are mutagenic at high concentration in the B. subtilis multigene sporulation test for mutagens; caffeine is a stronger mutagen than theophylline in this test. An unusually high fraction of the mutant colonies appear to be phenotypically identical, as judged by colonial morphology and microscopic appearance of the vegetative cells. These mutants do not bring about the pH increase normally associated with sporulation of B. subtilis; such behavior is frequently associated with lack of a functional tricarboxylic acid (TCA) cycle, essential for normal sporulation of this species. Similar mutants have not been noted in the course of screening a variety of well-known mutagens, including acriflavine. Caffeine is maximally effective in inducing these mutants about 10 min after germination commences. Adenosine greatly reduces the ability of caffeine to induce these mutants.
L E Sacks; K Mihara
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Mutation research     Volume:  117     ISSN:  0027-5107     ISO Abbreviation:  Mutat. Res.     Publication Date:  1983 Apr 
Date Detail:
Created Date:  1983-05-05     Completed Date:  1983-05-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0400763     Medline TA:  Mutat Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  55-65     Citation Subset:  IM    
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MeSH Terms
Acriflavine / toxicity*
Aminoacridines / toxicity*
Bacillus subtilis / drug effects*,  genetics,  growth & development
Caffeine / toxicity*
Mutagenicity Tests
Structure-Activity Relationship
Theophylline / toxicity*
Reg. No./Substance:
0/Aminoacridines; 0/Mutagens; 58-08-2/Caffeine; 58-55-9/Theophylline; 8048-52-0/Acriflavine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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