| Induction at high frequency of a unique phenotypic class of Bacillus subtilis mutants by methylxanthines. | |
| | |
MedLine Citation:
|
PMID: 6403857 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Caffeine and theophylline are mutagenic at high concentration in the B. subtilis multigene sporulation test for mutagens; caffeine is a stronger mutagen than theophylline in this test. An unusually high fraction of the mutant colonies appear to be phenotypically identical, as judged by colonial morphology and microscopic appearance of the vegetative cells. These mutants do not bring about the pH increase normally associated with sporulation of B. subtilis; such behavior is frequently associated with lack of a functional tricarboxylic acid (TCA) cycle, essential for normal sporulation of this species. Similar mutants have not been noted in the course of screening a variety of well-known mutagens, including acriflavine. Caffeine is maximally effective in inducing these mutants about 10 min after germination commences. Adenosine greatly reduces the ability of caffeine to induce these mutants. |
| | |
Authors:
|
L E Sacks; K Mihara |
Related Documents
:
|
6539177 - Carcinogenicity in mice of mutagenic compounds from glutamic acid and soybean globulin ... 2446127 - Effect of vitamins a, c and glutathione on the mutagenicity of benzo[a]pyrene mediated ... 3931067 - The effect of lysozyme and ethylenediaminetetraacetic acid on salmonella on broiler parts. 9566747 - Bioactivation of benzylic and allylic alcohols via sulfo-conjugation. 10232837 - Epr characterization of free radical intermediates formed during ultrasound exposure of... 1159027 - The direct gas chromatographic analysis of barbiturates as their sodium salts. |
Publication Detail:
|
Type: Comparative Study; Journal Article |
Journal Detail:
|
Title: Mutation research Volume: 117 ISSN: 0027-5107 ISO Abbreviation: Mutat. Res. Publication Date: 1983 Apr |
Date Detail:
|
Created Date: 1983-05-05 Completed Date: 1983-05-05 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0400763 Medline TA: Mutat Res Country: NETHERLANDS |
Other Details:
|
Languages: eng Pagination: 55-65 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acriflavine
/
toxicity* Aminoacridines / toxicity* Bacillus subtilis / drug effects*, genetics, growth & development Caffeine / toxicity* Mutagenicity Tests Mutagens* Mutation* Phenotype Structure-Activity Relationship Theophylline / toxicity* |
| Chemical | |
Reg. No./Substance:
|
0/Aminoacridines; 0/Mutagens; 58-08-2/Caffeine; 58-55-9/Theophylline; 8048-52-0/Acriflavine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Studies on the mutagenic activity of ascorbic acid in vitro and in vivo.
Next Document: gamma-Ray-induced mutations in male germ cells of a recombination-defective strain (c3G) of Drosophi...