Document Detail

Induction of astrocytic cyclooxygenase-2 in epileptic patients with hippocampal sclerosis.
MedLine Citation:
PMID:  12470703     Owner:  NLM     Status:  MEDLINE    
Induction of cyclooxygenase-2 (COX-2) has been described in a wide range of neurological diseases including animal models of epilepsy. The present study was undertaken to assess COX-2 expression in hippocampal biopsies from patients with therapy-refractive temporal lobe epilepsy (TLE). For this purpose, hippocampal CA1 subfield was dissected from epileptic patients with (n=5) or without (n=2) hippocampal sclerosis (HS). COX-2 expression was investigated using immunohistochemistry and semi-quantitative RT-PCR. COX-2 immunoreactivity in TLE patient material in the absence of HS was restricted to a few neurons of the hippocampus. In the presence of HS, on the other hand, a significant induction of astrocytic COX-2 immunoreactivity associated with a concomitant increase in the steady-state level of COX-2 mRNA was observed in the CA1 subfield. These findings suggest that induction of astrocytic COX-2 is implicated in the pathogenesis of HS in TLE and is consistent with the previous findings of increased concentrations of prostaglandins in the cerebrospinal fluid of these patients.
Paul Desjardins; Anny Sauvageau; Alain Bouthillier; Darren Navarro; Alan S Hazell; Christopher Rose; Roger F Butterworth
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neurochemistry international     Volume:  42     ISSN:  0197-0186     ISO Abbreviation:  Neurochem. Int.     Publication Date:  2003 Mar 
Date Detail:
Created Date:  2002-12-09     Completed Date:  2003-04-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8006959     Medline TA:  Neurochem Int     Country:  England    
Other Details:
Languages:  eng     Pagination:  299-303     Citation Subset:  IM    
Neuroscience Research Unit, C.H.U.M., Hôpital Saint-Luc, 1058 St. Denis Street, Montreal, Que., Canada H2X 3J4.
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MeSH Terms
Astrocytes / enzymology*
Cyclooxygenase 2
Epilepsy, Temporal Lobe / enzymology*,  pathology
Hippocampus / pathology*
Isoenzymes / biosynthesis*
Membrane Proteins
Prostaglandin-Endoperoxide Synthases / biosynthesis*
RNA / biosynthesis
Reverse Transcriptase Polymerase Chain Reaction
Sclerosis / enzymology*,  pathology
Reg. No./Substance:
0/Isoenzymes; 0/Membrane Proteins; 63231-63-0/RNA; EC 2; EC protein, human; EC Synthases

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