Document Detail

Induction of apoptosis and inhibition of DNA topoisomerase-I in K-562 cells by a marine microalgal polysaccharide.
MedLine Citation:
PMID:  10794503     Owner:  NLM     Status:  MEDLINE    
We have previously purified an extracellular polysaccharide, D-galactan sulfate associated with L(+)-lactic acid, produced from a marine microalga Dinoflagellate Gymnodinium sp. A3 (GA3). The GA3 polysaccharide, irrespective of presence or absence of lactic acid, exhibited significant cytotoxicity, which is based on an induction of apoptotic cell death, toward human myeloid leukemia K562 cells. Furthermore, we found that the GA3 polysaccharide with or without lactic acid possesses an inhibitory effect on topoisomerase-I (topo-I). The potent cytotoxic effect of GA3 polysaccharide may result from its inhibitory effect on topo-I, because the topo-I inhibition is known to trigger apoptotic cell death.
K Sogawa; T Yamada; T Sumida; H Hamakawa; H Kuwabara; M Matsuda; Y Muramatsu; H Kose; K Matsumoto; Y Sasaki; K Okutani; K Kondo; Y Monden
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Publication Detail:
Type:  Journal Article; Retracted Publication    
Journal Detail:
Title:  Life sciences     Volume:  66     ISSN:  0024-3205     ISO Abbreviation:  Life Sci.     Publication Date:  2000  
Date Detail:
Created Date:  2000-05-11     Completed Date:  2000-05-11     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  PL227-31     Citation Subset:  IM    
Second Department of Surgery, University of Tokushima School of Medicine, Japan.
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MeSH Terms
Apoptosis / drug effects*
DNA Topoisomerases, Type I / antagonists & inhibitors*
Dinoflagellida / chemistry*
Enzyme Inhibitors / pharmacology*
K562 Cells
Polysaccharides / pharmacology*
Reg. No./Substance:
0/Enzyme Inhibitors; 0/Polysaccharides; EC Topoisomerases, Type I
Retraction In:
Sogawa K, Yamada T, Sumida T, Hamakawa H, Kuwabara H, Matsuda M, Muramatsu Y, Kose H, Matsumoto K, Sasaki Y, Okutani K, Kondo K, Monden Y. Life Sci. 2002 Oct 11;71(21):2575   [PMID:  12408177 ]

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