Document Detail

Induction of apoptosis in human breast adenocarcinoma MCF-7 cells by pterocarnin A from the bark of Pterocarya stenoptera via the Fas-mediated pathway.
MedLine Citation:
PMID:  17414624     Owner:  NLM     Status:  MEDLINE    
Pterocarnin A, isolated from the bark of Pterocarya stenoptera (Juylandaceae), was investigated for its antiproliferative activity in human breast adenocarcinoma MCF-7 cells. To identify the anticancer mechanism of pterocarnin A, we assayed its effects on apoptosis, cell cycle distribution, and levels of p53, p21/WAF1, Fas/APO-1 receptor and Fas ligand. The results showed that pterocarnin A induced apoptosis of MCF-7 cells without mediation of p53 and p21/WAF1. We suggest that the Fas/Fas ligand apoptotic system is the main pathway of pterocarnin A-mediated apoptosis of MCF-7 cells. Our study reports here for the first time that the activity of the Fas/Fas ligand apoptotic system may participate in the antiproliferative activity of pterocarnin A in MCF-7 cells.
Po-Lin Kuo; Ya-Ling Hsu; Shu-Chiao Sung; Wen-Chiu Ni; Ta-Chen Lin; Chun-Ching Lin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Anti-cancer drugs     Volume:  18     ISSN:  0959-4973     ISO Abbreviation:  Anticancer Drugs     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-04-06     Completed Date:  2007-05-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9100823     Medline TA:  Anticancer Drugs     Country:  England    
Other Details:
Languages:  eng     Pagination:  555-62     Citation Subset:  IM    
Department of Biotechnology, Cell Biology Laboratory, Institute of Cosmetic Science, Chia-Nan University of Pharmacy and Science, Tainan, Taiwan, ROC.
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MeSH Terms
Adenocarcinoma / drug therapy*,  pathology
Antineoplastic Agents, Phytogenic / pharmacology*
Apoptosis / drug effects*
Blotting, Western
Breast Neoplasms / drug therapy*,  pathology
Caspase 8 / metabolism
Cell Cycle / drug effects
Cell Line, Tumor
Cell Proliferation / drug effects
Enzyme-Linked Immunosorbent Assay
Fas Ligand Protein / physiology*
Gallic Acid / analogs & derivatives*,  pharmacology
Genes, p53 / genetics
Glycosides / pharmacology*
Juglandaceae / chemistry*
Oncogene Protein p21(ras) / genetics
Plant Bark / chemistry
Reg. No./Substance:
0/Antineoplastic Agents, Phytogenic; 0/Fas Ligand Protein; 0/Glycosides; 0/pterocarnin A; 149-91-7/Gallic Acid; EC 3.4.22.-/Caspase 8; EC Protein p21(ras)

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