Document Detail

Induction of apoptosis by paclitaxel in human oral carcinoma cells.
MedLine Citation:
PMID:  16513327     Owner:  NLM     Status:  MEDLINE    
The present study investigated induction of apoptosis in NB-1 oral carcinoma cells by paclitaxel and the expression of Bcl-2 and Bax in relation to this apoptotic cell death. Paclitaxel induced apoptotic cell death in NB-1 cells in a dose- and a time-dependent manner. The present results suggest that paclitaxel can induce apoptosis of NB-1 cells, which may be mediated by down-regulation of Bcl-2 together with up-regulation of Bax.
M Nonaka; H Ikeda; A Fujisawa; M Uehara; T Inokuchi
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Publication Detail:
Type:  Journal Article     Date:  2006-02-28
Journal Detail:
Title:  International journal of oral and maxillofacial surgery     Volume:  35     ISSN:  0901-5027     ISO Abbreviation:  Int J Oral Maxillofac Surg     Publication Date:  2006 Jul 
Date Detail:
Created Date:  2006-06-19     Completed Date:  2006-08-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8605826     Medline TA:  Int J Oral Maxillofac Surg     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  649-52     Citation Subset:  D; IM    
Department of Developmental and Reconstructive Medicine, Division of Oral & Maxillofacial Surgical Reconstruction and Functional Restoration, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8588, Japan.
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MeSH Terms
Antineoplastic Agents, Phytogenic / pharmacology*,  therapeutic use
Apoptosis / drug effects*
Carcinoma, Squamous Cell / drug therapy*,  metabolism
Cell Line, Tumor / drug effects
Cell Survival / drug effects
Dose-Response Relationship, Drug
Mouth Neoplasms / drug therapy*,  metabolism
Paclitaxel / pharmacology*,  therapeutic use
Proto-Oncogene Proteins c-bcl-2 / biosynthesis
bcl-2-Associated X Protein / biosynthesis
Reg. No./Substance:
0/Antineoplastic Agents, Phytogenic; 0/Proto-Oncogene Proteins c-bcl-2; 0/bcl-2-Associated X Protein; 33069-62-4/Paclitaxel

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