| Induction of apoptosis by paclitaxel in human oral carcinoma cells. | |
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MedLine Citation:
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PMID: 16513327 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The present study investigated induction of apoptosis in NB-1 oral carcinoma cells by paclitaxel and the expression of Bcl-2 and Bax in relation to this apoptotic cell death. Paclitaxel induced apoptotic cell death in NB-1 cells in a dose- and a time-dependent manner. The present results suggest that paclitaxel can induce apoptosis of NB-1 cells, which may be mediated by down-regulation of Bcl-2 together with up-regulation of Bax. |
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Authors:
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M Nonaka; H Ikeda; A Fujisawa; M Uehara; T Inokuchi |
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Publication Detail:
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Type: Journal Article Date: 2006-02-28 |
Journal Detail:
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Title: International journal of oral and maxillofacial surgery Volume: 35 ISSN: 0901-5027 ISO Abbreviation: Int J Oral Maxillofac Surg Publication Date: 2006 Jul |
Date Detail:
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Created Date: 2006-06-19 Completed Date: 2006-08-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8605826 Medline TA: Int J Oral Maxillofac Surg Country: Denmark |
Other Details:
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Languages: eng Pagination: 649-52 Citation Subset: D; IM |
Affiliation:
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Department of Developmental and Reconstructive Medicine, Division of Oral & Maxillofacial Surgical Reconstruction and Functional Restoration, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8588, Japan. mnonaka@net.nagasaki-u.ac.jp |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antineoplastic Agents, Phytogenic
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pharmacology*,
therapeutic use Apoptosis / drug effects* Carcinoma, Squamous Cell / drug therapy*, metabolism Cell Line, Tumor / drug effects Cell Survival / drug effects Dose-Response Relationship, Drug Humans Mouth Neoplasms / drug therapy*, metabolism Paclitaxel / pharmacology*, therapeutic use Proto-Oncogene Proteins c-bcl-2 / biosynthesis bcl-2-Associated X Protein / biosynthesis |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents, Phytogenic; 0/Proto-Oncogene Proteins c-bcl-2; 0/bcl-2-Associated X Protein; 33069-62-4/Paclitaxel |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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