| Induction of apoptosis by a novel indirubin-5-nitro-3'-monoxime, a CDK inhibitor, in human lung cancer cells. | |
| | |
MedLine Citation:
|
PMID: 15993584 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
A novel indirubin analog, indirubin-5-nitro-3'-monoxime, inhibited cell proliferation against various human cancer cells. Additional studies indicate that the mechanism of action of this analog against human lung cancer cells might be to arrest cell cycle progression at the G2/M phase and induce apoptosis via p53- and mitochondria-dependent pathways. These data suggest that indirubin-5-nitro-3'-monoxime might be a novel candidate for development of anticancer agents. |
| | |
Authors:
|
Jong-Won Lee; Myoung Ju Moon; Hye-Young Min; Hwa-Jin Chung; Eun-Jung Park; Hyen Joo Park; Ji-Young Hong; Yong-Chul Kim; Sang Kook Lee |
Related Documents
:
|
2025284 - A dna crosslinking drug alters synthesis of several low molecular weight proteins in hu... 14701864 - Adamts4 (aggrecanase-1) activation on the cell surface involves c-terminal cleavage by ... 8917374 - Expression pattern of nuclear p53 is unique in cos-1 cells. 19013184 - Bypass of hexavalent chromium-induced growth arrest by a protein tyrosine phosphatase i... 14731794 - Cell polarity and epithelial oncogenesis. 9130714 - Induction of apoptosis by the transcription factor c-jun. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Bioorganic & medicinal chemistry letters Volume: 15 ISSN: 0960-894X ISO Abbreviation: Bioorg. Med. Chem. Lett. Publication Date: 2005 Sep |
Date Detail:
|
Created Date: 2005-08-02 Completed Date: 2005-10-18 Revised Date: 2009-11-19 |
Medline Journal Info:
|
Nlm Unique ID: 9107377 Medline TA: Bioorg Med Chem Lett Country: England |
Other Details:
|
Languages: eng Pagination: 3948-52 Citation Subset: IM |
Affiliation:
|
College of Pharmacy, Ewha Womans University, 11-1 Daehyun-dong, Seodaemun-ku, Seoul 120-750, Republic of Korea. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Antibiotics, Antineoplastic
/
chemical synthesis,
pharmacology Apoptosis / drug effects* Cell Line, Tumor Cell Proliferation / drug effects Cyclin-Dependent Kinases / antagonists & inhibitors* Humans Indoles / chemical synthesis, pharmacology Interphase / drug effects Lung Neoplasms / drug therapy*, pathology Structure-Activity Relationship |
| Chemical | |
Reg. No./Substance:
|
0/Antibiotics, Antineoplastic; 0/Indoles; 479-41-4/indirubin; EC 2.7.11.22/Cyclin-Dependent Kinases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Synthesis of novel curcumin mimics with asymmetrical units and their anti-angiogenic activity.
Next Document: Synthesis of benzoyl phenyl benzoates as effective inhibitors for phospholipase A2 and hyaluronidase...