| Induction of apoptosis by the green tea flavonol (-)-epigallocatechin-3-gallate in human endothelial ECV 304 cells. | |
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MedLine Citation:
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PMID: 12530089 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have previously shown that treatment with (-)-epigallocatechin-3-gallate (EGCG) inhibited vascularity and tumor growth in human colon cancer xenografts in nude mice (Jung et al: Br J Cancer 84, 2001). In this study, we examined whether endothelial cell death by EGCG is mediated by apoptosis and which molecular mechanisms are involved in this process. EGCG was found to suppress cell growth and induce apoptosis largely through mitochondrial depolarization, activation of caspase-3 and cleavage of DNA fragmentation factor-45 in human endothelial ECV 304 cells. The induction of apoptosis by EGCG was confirmed by cleaved and condensed nuclear chromatin and DNA hypoploidy. These results suggest that EGCG may exert at least part of its anticancer effect by inhibiting angiogenesis through inducing endothelial apoptosis. |
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Authors:
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Hyeon G Yoo; Boo A Shin; Ju C Park; Hong S Kim; Won J Kim; Kee O Chay; Bong W Ahn; Rae K Park; Lee M Ellis; Young D Jung |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Anticancer research Volume: 22 ISSN: 0250-7005 ISO Abbreviation: Anticancer Res. Publication Date: 2002 Nov-Dec |
Date Detail:
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Created Date: 2003-01-17 Completed Date: 2003-01-31 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8102988 Medline TA: Anticancer Res Country: Greece |
Other Details:
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Languages: eng Pagination: 3373-8 Citation Subset: IM |
Affiliation:
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Chonnam University Research Institute of Medical Sciences, Chonnam National University Medical School, Kwangju, Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Angiogenesis Inhibitors
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pharmacology Antineoplastic Agents / pharmacology* Apoptosis / drug effects*, physiology Caspase 3 Caspases / metabolism Catechin / analogs & derivatives*, pharmacology* Cell Division / drug effects Cells, Cultured Endothelium, Vascular / cytology, drug effects*, enzymology Enzyme Activation / drug effects Humans Proteins / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Angiogenesis Inhibitors; 0/Antineoplastic Agents; 0/DNA fragmentation factor, human; 0/Proteins; 154-23-4/Catechin; 989-51-5/epigallocatechin gallate; EC 3.4.22.-/CASP3 protein, human; EC 3.4.22.-/Caspase 3; EC 3.4.22.-/Caspases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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