Document Detail


Induction of anti-human immunodeficiency virus (HIV) neutralizing antibodies in rabbits immunized with recombinant HIV--hepatitis B surface antigen particles.
MedLine Citation:
PMID:  2460859     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Fragments of the human immunodeficiency virus (HIV) envelope coding region have been fused with the hepatitis B virus envelope middle protein. In this system, HIV antigenic determinants are exposed at the surface of a highly antigenic structure, the hepatitis B surface antigen particle. Immunization of rabbits with these particles elicited antibodies directed against both parts of the hybrid protein. One of the rabbit antisera not only exhibited a neutralizing effect on the original HIV1 isolate but also on a divergent Zairian isolate. The HIV sequence in this recombinant is 84 amino acids long and contains conserved and variable domains and a region critical for interaction with the CD4 receptor. Such recombinant antigens could be primary elements in the design of a polyvalent vaccine.
Authors:
M L Michel; M Mancini; E Sobczak; V Favier; D Guetard; E M Bahraoui; P Tiollais
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  85     ISSN:  0027-8424     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  1988 Nov 
Date Detail:
Created Date:  1988-12-09     Completed Date:  1988-12-09     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  7957-61     Citation Subset:  IM; X    
Affiliation:
Unité de Recombinaison et Expression Génétique, Institut National de la Santé et de la Recherche Médicale Unité 163, Paris, France.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antibody Formation
Base Sequence
Epitopes / analysis
HIV Antibodies / biosynthesis*
Hepatitis B Surface Antigens / administration & dosage,  immunology*
Humans
Immune Sera
Molecular Sequence Data
Rabbits
Recombinant Proteins / immunology
Transfection
Chemical
Reg. No./Substance:
0/Epitopes; 0/HIV Antibodies; 0/Hepatitis B Surface Antigens; 0/Immune Sera; 0/Recombinant Proteins
Comments/Corrections

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