| Induction of anaesthesia with sevoflurane and isoflurane in the rabbit. | |
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MedLine Citation:
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PMID: 10759391 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of induction of anaesthesia with sevoflurane and isoflurane were studied in rabbits. All rabbits had periods of apnoea (ranging from 30-180 s) during induction which resulted in moderate hypercapnia and acidosis. Arterial pCO2 rose from 4.1 +/- 0.3 kPa to a peak of 7.6 +/- 0.4 kPa (mean +/- SD) (both agents). All animals showed a significant reduction in heart rate (P < 0.05). Heart rate (HR) fell from 226 +/- 33 to a minimum during induction of 57 +/- 32 (sevoflurane) and 199 +/- 41 to 45 +/- 11 (isoflurane). Most animals struggled violently during induction. Use of sevoflurane did not prevent the breath-holding response seen during induction of anaesthesia with other volatile anaesthetics in this species, and the severe apnoea which occurs may represent a significant hazard. The behaviour of the animals indicated that both sevoflurane and isoflurane are aversive, suggesting that this technique should be avoided whenever possible. |
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Authors:
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P A Flecknell; J V Roughan; P Hedenqvist |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Laboratory animals Volume: 33 ISSN: 0023-6772 ISO Abbreviation: Lab. Anim. Publication Date: 1999 Jan |
Date Detail:
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Created Date: 2000-05-03 Completed Date: 2000-05-03 Revised Date: 2009-09-29 |
Medline Journal Info:
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Nlm Unique ID: 0112725 Medline TA: Lab Anim Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 41-6 Citation Subset: IM |
Affiliation:
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Comparative Biology Centre, University of Newcastle, Newcastle upon Tyne, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anesthesia, Inhalation
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veterinary* Anesthetics, Inhalation* Animals Apnea / veterinary Blood Gas Analysis / veterinary Blood Pressure / drug effects Electrocardiography / veterinary Female Heart Rate / drug effects Isoflurane* Masks / veterinary Methyl Ethers* Rabbits / physiology* Random Allocation Respiration / drug effects Restraint, Physical / veterinary |
| Grant Support | |
ID/Acronym/Agency:
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//Wellcome Trust |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics, Inhalation; 0/Methyl Ethers; 26675-46-7/Isoflurane; 28523-86-6/sevoflurane |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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