Document Detail

Induction of anaesthesia with sevoflurane and isoflurane in the rabbit.
MedLine Citation:
PMID:  10759391     Owner:  NLM     Status:  MEDLINE    
The effects of induction of anaesthesia with sevoflurane and isoflurane were studied in rabbits. All rabbits had periods of apnoea (ranging from 30-180 s) during induction which resulted in moderate hypercapnia and acidosis. Arterial pCO2 rose from 4.1 +/- 0.3 kPa to a peak of 7.6 +/- 0.4 kPa (mean +/- SD) (both agents). All animals showed a significant reduction in heart rate (P < 0.05). Heart rate (HR) fell from 226 +/- 33 to a minimum during induction of 57 +/- 32 (sevoflurane) and 199 +/- 41 to 45 +/- 11 (isoflurane). Most animals struggled violently during induction. Use of sevoflurane did not prevent the breath-holding response seen during induction of anaesthesia with other volatile anaesthetics in this species, and the severe apnoea which occurs may represent a significant hazard. The behaviour of the animals indicated that both sevoflurane and isoflurane are aversive, suggesting that this technique should be avoided whenever possible.
P A Flecknell; J V Roughan; P Hedenqvist
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Laboratory animals     Volume:  33     ISSN:  0023-6772     ISO Abbreviation:  Lab. Anim.     Publication Date:  1999 Jan 
Date Detail:
Created Date:  2000-05-03     Completed Date:  2000-05-03     Revised Date:  2009-09-29    
Medline Journal Info:
Nlm Unique ID:  0112725     Medline TA:  Lab Anim     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  41-6     Citation Subset:  IM    
Comparative Biology Centre, University of Newcastle, Newcastle upon Tyne, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Anesthesia, Inhalation / veterinary*
Anesthetics, Inhalation*
Apnea / veterinary
Blood Gas Analysis / veterinary
Blood Pressure / drug effects
Electrocardiography / veterinary
Heart Rate / drug effects
Masks / veterinary
Methyl Ethers*
Rabbits / physiology*
Random Allocation
Respiration / drug effects
Restraint, Physical / veterinary
Grant Support
//Wellcome Trust
Reg. No./Substance:
0/Anesthetics, Inhalation; 0/Methyl Ethers; 26675-46-7/Isoflurane; 28523-86-6/sevoflurane

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Short-term immobilization of mice by methohexitone.
Next Document:  EEG evaluation of reflex testing as assessment of depth of pentobarbital anaesthesia in the rat.