| Induction of Treg cells in the mouse colonic mucosa: A central mechanism to maintain host-microbiota homeostasis. | |
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MedLine Citation:
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PMID: 22172550 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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CD4(+) regulatory T (Treg) cells expressing the transcription factor forkhead box P3 (Foxp3) play a critical role in maintaining immunological homeostasis. Treg cells are highly abundant in the mouse intestinal lamina propria, particularly in the colon. Recent studies using germ-free and gnotobiotic mice have revealed that specific components of the intestinal microbiota influence the number and function of Treg cells. Substantial changes in the composition of microbiota have been associated with inflammatory bowel disease. In this review, we will discuss recent findings that associate intestinal microbiota in mice with Treg responses and with the maintenance of intestinal immune homeostasis. |
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Authors:
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Takeshi Tanoue; Kenya Honda |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-13 |
Journal Detail:
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Title: Seminars in immunology Volume: - ISSN: 1096-3618 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9009458 Medline TA: Semin Immunol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Immunology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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