| Induction of Th1 immune responses to Japanese cedar pollen allergen (Cry j 1) in mice immunized with Cry j 1 conjugated with CpG oligodeoxynucleotide. | |
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MedLine Citation:
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PMID: 20638725 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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We determined whether a major Japanese cedar pollen allergen (Cry j 1) conjugated with CpG oligodeoxynucleotide would enhance allergen-specific Th1 responses in mice. Cry j 1 conjugated with CpG (Cry j 1-CpG) induced IL-12 in the spleen cells of naïve mice. Cry j 1-CpG immunization of BALB/c mice suppressed anti-Cry j 1 IgE response and enhanced anti-Cry j 1 IgG(2a) to subsequent Cry j 1 and alum adjuvant injection. CD4(+)T cells isolated from the spleens in mice immunized with Cry j 1-CpG produced higher IFN-γ levels than did CD4(+)T cells obtained from mice as negative controls. Our results suggested that Cry j 1-CpG immunization can induce Cry j 1-specific Th1 immune responses, thereby inhibiting IgE response to the pollen allergen. |
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Authors:
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Y Kaburaki; T Fujimura; K Kurata; K Masuda; M Toda; H Yasueda; K Chida; S Kawarai; M Sakaguchi |
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Publication Detail:
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Type: Journal Article Date: 2010-07-17 |
Journal Detail:
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Title: Comparative immunology, microbiology and infectious diseases Volume: 34 ISSN: 1878-1667 ISO Abbreviation: Comp. Immunol. Microbiol. Infect. Dis. Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-02-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7808924 Medline TA: Comp Immunol Microbiol Infect Dis Country: England |
Other Details:
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Languages: eng Pagination: 157-61 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Animal Resource Sciences, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Yayoi 1-1-1, Bunkyo-ku, Tokyo 113-8657, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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