| Induction of T-helper cell response to hepatitis B core antigen in chronic hepatitis B: a major factor in activation of the host immune response to the hepatitis B virus. | |
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MedLine Citation:
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PMID: 7557849 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The T helper (Th) cell response to hepatitis B core antigen (HBcAg) was analyzed in 76 chronic hepatitis B virus (HBV) carriers with varying degrees of hepatic inflammation and HBV replication. Fifty-five patients had active viral replication, 28 with minimal histological changes and normal alanine transaminase (ALT) and 27 with active hepatic inflammation and elevated ALT. The remaining 21 chronic hepatitis B surface antigen (HBsAg) carriers had undetectable HBV replication, minimal histological activity, and normal ALT. In addition, 34 chronic HBV carriers were studied prospectively during treatment with alpha-interferon. The HBcAg-specific Th cell response was evaluated by a proliferative assay using 3H-thymidine uptake and gamma-interferon production by peripheral blood mononuclear cells. The proliferative response and gamma-interferon production of patients with active hepatic inflammation were significantly higher than in patients with minimal histological changes and in controls. In the longitudinal analysis during alpha-interferon treatment, 22 of 34 patients sustained an ALT flare accompanied by a parallel, significant Th cell response, which preceded or coincided with the ALT flare. The elevation in the Th cell response and the ALT flare were followed by a significant rise in the serum immunoglobulin (Ig) M anti-HBc index. Ten of twenty-two patients with an enhanced Th cell response and an ALT flare seroconverted after alpha-interferon treatment. The Th cell activity in the 10 responders rapidly subsided after hepatitis B e antigen (HBeAg) to anti-HBe seroconversion, whereas in the 12 nonresponders it remained elevated.(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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G Marinos; F Torre; S Chokshi; M Hussain; B E Clarke; D J Rowlands; A L Eddleston; N V Naoumov; R Williams |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Hepatology (Baltimore, Md.) Volume: 22 ISSN: 0270-9139 ISO Abbreviation: Hepatology Publication Date: 1995 Oct |
Date Detail:
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Created Date: 1995-11-03 Completed Date: 1995-11-03 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8302946 Medline TA: Hepatology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1040-9 Citation Subset: IM |
Affiliation:
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Institute of Liver Studies, King's College School of Medicine and Dentistry, London, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Alanine Transaminase
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blood Antiviral Agents / therapeutic use Chronic Disease DNA, Viral / blood Hepatitis B / immunology*, therapy, virology Hepatitis B Antibodies / blood Hepatitis B Core Antigens / immunology* Hepatitis B e Antigens / immunology Hepatitis B virus / genetics, immunology, physiology Humans Interferon-alpha / therapeutic use Interferon-gamma / biosynthesis Leukocytes, Mononuclear / metabolism Prospective Studies T-Lymphocytes, Helper-Inducer / immunology* Virus Replication |
| Chemical | |
Reg. No./Substance:
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0/Antiviral Agents; 0/DNA, Viral; 0/Hepatitis B Antibodies; 0/Hepatitis B Core Antigens; 0/Hepatitis B e Antigens; 0/Interferon-alpha; 82115-62-6/Interferon-gamma; EC 2.6.1.2/Alanine Transaminase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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