Document Detail

Induction of S phase by G1 regulatory factors.
MedLine Citation:
PMID:  10577389     Owner:  NLM     Status:  MEDLINE    
The first gap phase (G1) in the mammalian cell cycle plays a pivotal role in determining whether or not cells are to initiate DNA replication. Progression through G1 phase and transition into S phase are positively and negatively regulated by a series of factors, collectively termed G1 regulators. Among them, D-type G1 cyclins and a Cdk inhibitor, p27Kip1, function as the target of growth factors to integrate extracellular signals into cell cycle regulators. Another G1 cyclin, cyclin E, and a transcription factor E2F are situated the furthest downstream of known G1 regulators and seem to be directly involved in the initiation of chromosomal DNA replication. Alterations in G1 regulator genes are often present in human tumors, indicating that G1 regulators participate in tumor suppressive mechanisms as well as in cell proliferation.
J Kato
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  1999-12-01
Journal Detail:
Title:  Frontiers in bioscience : a journal and virtual library     Volume:  4     ISSN:  1093-4715     ISO Abbreviation:  Front. Biosci.     Publication Date:  1999 Dec 
Date Detail:
Created Date:  1999-12-08     Completed Date:  1999-12-08     Revised Date:  2012-06-25    
Medline Journal Info:
Nlm Unique ID:  9709506     Medline TA:  Front Biosci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  D787-92     Citation Subset:  IM    
Graduate School of Biological Sciences, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, Nara 630-0101, Japan.
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MeSH Terms
CDC2-CDC28 Kinases*
Carrier Proteins*
Cell Cycle*
Cell Cycle Proteins*
Cyclin D
Cyclin E / physiology
Cyclin-Dependent Kinase 2
Cyclin-Dependent Kinase 4
Cyclin-Dependent Kinase Inhibitor p27
Cyclin-Dependent Kinases / metabolism*,  physiology
Cyclins / metabolism*
DNA-Binding Proteins*
E2F Transcription Factors
G1 Phase*
Microtubule-Associated Proteins / metabolism
Protein-Serine-Threonine Kinases / physiology
Proto-Oncogene Proteins*
Retinoblastoma-Binding Protein 1
S Phase*
Transcription Factor DP1
Transcription Factors / physiology
Tumor Suppressor Proteins*
Reg. No./Substance:
0/Carrier Proteins; 0/Cell Cycle Proteins; 0/Cyclin D; 0/Cyclin E; 0/Cyclins; 0/DNA-Binding Proteins; 0/E2F Transcription Factors; 0/Microtubule-Associated Proteins; 0/Proto-Oncogene Proteins; 0/Retinoblastoma-Binding Protein 1; 0/Transcription Factor DP1; 0/Transcription Factors; 0/Tumor Suppressor Proteins; 147604-94-2/Cyclin-Dependent Kinase Inhibitor p27; EC Kinases; EC Kinases; EC protein, human; EC protein, human; EC Kinase 2; EC Kinase 4; EC Kinases

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