Document Detail

Induction of NMDA receptor-dependent long-term depression in visual cortex does not require metabotropic glutamate receptors.
MedLine Citation:
PMID:  10601487     Owner:  NLM     Status:  MEDLINE    
We tested the role of group I mGluRs in the induction of long-term depression (LTD) in the visual cortex, using the novel mGluR antagonist LY341495 and mice lacking mGluR5, the predominant phosphoinositide (PI)-linked mGluR in the visual cortex. We find that LY341495 is a potent blocker of glutamate-stimulated PI hydrolysis in visual cortical synaptoneurosomes, and that it effectively antagonizes the actions of the mGluR agonist 1S, 3R-aminocyclopentane-1,3-dicarboxylic acid (ACPD) on synaptic transmission in visual cortical slices. However, LY341495 has no effect on the induction of LTD by low-frequency stimulation. Furthermore, mice lacking mGluR5 show normal NMDA receptor-dependent LTD. These results indicate that group I mGluR activation is not required for the induction of NMDA receptor-dependent LTD in the visual cortex.
N B Sawtell; K M Huber; J C Roder; M F Bear
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of neurophysiology     Volume:  82     ISSN:  0022-3077     ISO Abbreviation:  J. Neurophysiol.     Publication Date:  1999 Dec 
Date Detail:
Created Date:  2000-02-03     Completed Date:  2000-02-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375404     Medline TA:  J Neurophysiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  3594-7     Citation Subset:  IM    
Department of Neuroscience, Howard Hughes Medical Institute, Brown University, Providence, Rhode Island 02912, USA.
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MeSH Terms
Amino Acids / pharmacology
Cycloleucine / analogs & derivatives,  pharmacology
Depression, Chemical
Excitatory Amino Acid Antagonists / pharmacology
Methoxyhydroxyphenylglycol / analogs & derivatives,  pharmacology
Mice, Knockout
Neuronal Plasticity / drug effects,  physiology*
Phosphatidylinositols / metabolism
Receptors, Metabotropic Glutamate / agonists,  antagonists & inhibitors,  physiology*
Receptors, N-Methyl-D-Aspartate / antagonists & inhibitors,  genetics,  physiology*
Synaptosomes / drug effects,  metabolism
Visual Cortex / drug effects,  physiology*
Xanthenes / pharmacology
Reg. No./Substance:
0/Amino Acids; 0/Excitatory Amino Acid Antagonists; 0/LY 341495; 0/Phosphatidylinositols; 0/Receptors, Metabotropic Glutamate; 0/Receptors, N-Methyl-D-Aspartate; 0/Xanthenes; 111900-32-4/1-amino-1,3-dicarboxycyclopentane; 3343-19-9/dihydroxyphenylethylene glycol; 52-52-8/Cycloleucine; 534-82-7/Methoxyhydroxyphenylglycol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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