| Induction of NGFI-A mRNA following middle cerebral artery occlusion in rats: in situ hybridization study. | |
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MedLine Citation:
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PMID: 8084481 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Middle cerebral artery (MCA) occlusion in halothane-anesthetized rats induced the zinc finger gene, NGFI-A, in brain. In situ hybridization studies showed that NGFI-A was induced throughout all of the cortex following MCA occlusion. By 24 h after MCA occlusion there was little expression of NGFI-A mRNA in the core of the MCA infarct, but the mRNA was still induced in all of cortex outside the infarct. MCA occlusion also induced this gene in subcortical structures: ipsilateral medial striatum; most of thalamus including medial and lateral geniculate nuclei; substantia nigra; and hippocampus at 4 h of MCA occlusion which generally disappeared by 24 h of MCA occlusion. Most of these structures, except for the striatum, are not supplied by the MCA. These data show that changes in brain gene expression can occur in many regions remote from an infarction. |
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Authors:
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H Kinouchi; F R Sharp; P H Chan; J Koistinaho; S M Sagar; T Yoshimoto |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Neuroscience letters Volume: 171 ISSN: 0304-3940 ISO Abbreviation: Neurosci. Lett. Publication Date: 1994 Apr |
Date Detail:
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Created Date: 1994-10-10 Completed Date: 1994-10-10 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7600130 Medline TA: Neurosci Lett Country: IRELAND |
Other Details:
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Languages: eng Pagination: 163-6 Citation Subset: IM |
Affiliation:
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Division of Neurosurgery, Institute of Brain Diseases, Tohoku University School of Medicine, Sendai, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Autoradiography Brain / pathology Brain Ischemia / metabolism*, pathology Cerebral Arteries / physiology In Situ Hybridization Male Oligonucleotides / biosynthesis RNA, Messenger / biosynthesis* Rats Rats, Sprague-Dawley Zinc Fingers / genetics, physiology* |
| Chemical | |
Reg. No./Substance:
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0/Oligonucleotides; 0/RNA, Messenger |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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