Document Detail


Induction of NGF synthesis in astrocytes by onjisaponins of Polygala tenuifolia, constituents of kampo (Japanese herbal) medicine, Ninjin-yoei-to.
MedLine Citation:
PMID:  12725562     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of a kampo medicine, Ninjin-yoei-to (NYT; Ren-shen-yang-rong-tang in Chinese) on nerve growth factor (NGF) secretion from the cultured rat astrocytes was examined in vitro. When rat embryo astrocytes were cultured in the presence of NYT for 24 h, the amount of NGF in the medium was significantly increased in a dose dependent manner. Among 14 kinds of component herbs in NYT, the roots of Polygala tenuifolia and roots of Panax ginseng extracts increased NGF levels from the astrocytes. Saponin fraction from the roots of P. tenuifolia enhanced the production of NGF, however phenolic glycoside fraction showed no effect. Onjisaponins A, B, E, F and G as major saponins of the root of P. tenuifolia strongly increased the NGF level, whereas ginsenosides Rb1 and Rg1 did not affect the NGF level. Onjisaponin F also induced ChAT mRNA level in rat basal forebrain cells. These results indicate the possibility that NYT and/or onjisaponins in P. tenuifolia may have potential therapeutic effects for the treatment of Alzheimer disease patients.
Authors:
T Yabe; H Tuchida; H Kiyohara; T Takeda; H Yamada
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Phytomedicine : international journal of phytotherapy and phytopharmacology     Volume:  10     ISSN:  0944-7113     ISO Abbreviation:  Phytomedicine     Publication Date:  2003 Mar 
Date Detail:
Created Date:  2003-05-02     Completed Date:  2003-06-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9438794     Medline TA:  Phytomedicine     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  106-14     Citation Subset:  IM    
Affiliation:
Oriental Medicine Research Center, The Kitasato Institute, Tokyo, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Astrocytes / drug effects,  metabolism*
Cells, Cultured
Drugs, Chinese Herbal / pharmacology*
Enzyme-Linked Immunosorbent Assay
Ginsenosides / pharmacology
Medicine, Kampo
Nerve Growth Factor / biosynthesis*,  drug effects,  genetics
Panax
Plant Extracts / pharmacology
Plant Roots / chemistry,  metabolism
Polygala*
RNA, Messenger / genetics,  metabolism
Rats
Saponins / chemistry,  isolation & purification,  pharmacology*
Triterpenes / chemistry,  isolation & purification,  pharmacology*
Chemical
Reg. No./Substance:
0/Drugs, Chinese Herbal; 0/Ginsenosides; 0/Plant Extracts; 0/RNA, Messenger; 0/Saponins; 0/Triterpenes; 0/ginsenoside Rb1; 0/onjisaponin A; 0/onjisaponin B; 0/onjisaponin E; 0/onjisaponin F; 0/onjisaponin G; 0/ren-shen-yang-rong-tang; 22427-39-0/ginsenoside Rg1; 9061-61-4/Nerve Growth Factor

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