Document Detail

Induction of spermidine/spermine N1-acetyltransferase in rat tissues by polyamines.
MedLine Citation:
PMID:  4062898     Owner:  NLM     Status:  MEDLINE    
Treatment of rats with spermidine, spermine or sym-norspermidine led to a substantial induction of spermidine/spermine N1-acetyltransferase activity in liver, kidney and lung. The increase in this enzyme, which was determined independently of other acetylases by using a specific antiserum, accounted for all of the increased acetylase activity in extracts from rats treated with these polyamines. Spermine was the most active inducer, and the greatest effect was seen in liver. Liver spermidine/spermine N1-acetyltransferase activity was increased about 300-fold within 6 h of treatment with 0.3 mmol/kg doses of spermine; activity in kidney increased 30-fold and activity in the lung 15-fold under these conditions. The increased spermidine/spermine N1-acetyltransferase activity led to a large increase in the liver putrescine content and a decline in spermidine. These changes are due to the oxidation by polyamine oxidase of the N1-acetylspermidine formed by the acetyltransferase. Our results indicated that spermidine was the preferred substrate in vivo of the acetylase/oxidase pathway for the conversion of the higher polyamines into putrescine. The induction of the spermidine/spermine N1-acetyltransferase by polyamines may provide a mechanism by which excess polyamines can be removed.
A E Pegg; B G Erwin
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Biochemical journal     Volume:  231     ISSN:  0264-6021     ISO Abbreviation:  Biochem. J.     Publication Date:  1985 Oct 
Date Detail:
Created Date:  1985-12-19     Completed Date:  1985-12-19     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2984726R     Medline TA:  Biochem J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  285-9     Citation Subset:  IM    
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MeSH Terms
Acetyltransferases / biosynthesis*
Dose-Response Relationship, Drug
Enzyme Induction / drug effects
Kidney / enzymology
Liver / enzymology
Lung / enzymology
Polyamines / metabolism,  pharmacology*
Rats, Inbred Strains
Spermidine / pharmacology
Spermine / pharmacology
Grant Support
Reg. No./Substance:
0/Polyamines; 124-20-9/Spermidine; 71-44-3/Spermine; EC 2.3.1.-/Acetyltransferases; EC N-acetyltransferase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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