| Induction of labor: a comparative study of intravaginal misoprostol and dinoprostone. | |
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MedLine Citation:
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PMID: 20708519 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To compare the efficacy and safety of intravaginal misoprostol and dinoprostone for elective induction of labor in nulliparous women with an unfavorable cervix. MATERIALS AND METHODS: A quasi-experimental study was conducted in Bahawal Victoria Hospital, Bahawalpur, Pakistan, from July 1, 2005 to August 31, 2006. A total of 120 primigravid women with gestational ages of > 40 weeks to < 42 weeks were divided into two groups. Group A (n = 60) was given 50 microg of misoprostol and Group B (n = 60) was given 3 mg of dinoprostone every 6 hours, for a maximum of three doses. RESULTS: The induction to onset of significant uterine contractions and delivery intervals were lower in Group A than in Group B (6.1 vs. 7.2 hours; p = 0.16; and 8.2 vs. 11.0 hours; p = 0.007, respectively). Group A had a lower cesarean section rate than Group B (7% vs. 30%; p = 0.003), but a higher rate of uterine hyperstimulation (10% vs. 3%; p = 0.16), tachysystole (17% vs. 3%; p = 0.02), and neonatal admissions to the intensive care unit within 24 hours of delivery (4 vs. 3; p = 0.71) and after 24 hours (2 vs. 1; p = 0.56) than Group B. CONCLUSION: Vaginal misoprostol is more effective than dinoprostone for the elective induction of labor beyond 40 weeks of gestation, but is associated with more uterine hyperstimulation, tachysystole, and neonatal intensive care unit admissions. |
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Authors:
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Aqueela Ayaz; Saima Shaukat; Mian Usman Farooq; Khalid Mehmood; Iftikhar Ahmad; Muhammad Luqman Ali Bahoo |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Taiwanese journal of obstetrics & gynecology Volume: 49 ISSN: 1875-6263 ISO Abbreviation: Taiwan J Obstet Gynecol Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-08-16 Completed Date: 2010-12-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101213819 Medline TA: Taiwan J Obstet Gynecol Country: China |
Other Details:
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Languages: eng Pagination: 151-5 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Taiwan Association of Obstetrics and Gynecology. Published by Elsevier B.V. All rights reserved. |
Affiliation:
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Department of Obstetrics and Gynecology, Hera General Hospital, Makkah, Saudi Arabia. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Intravaginal Adult Cesarean Section / statistics & numerical data Dinoprostone / therapeutic use* Female Humans Infant, Newborn Intensive Care Units, Neonatal Labor, Induced / methods* Misoprostol / therapeutic use* Oxytocics / therapeutic use* Patient Admission / statistics & numerical data Pregnancy Uterine Contraction / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Oxytocics; 363-24-6/Dinoprostone; 59122-46-2/Misoprostol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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