Document Detail

Induction of DNA Damage and Caspase-Independent Programmed Cell Death by Vitamin E.
MedLine Citation:
PMID:  22172208     Owner:  NLM     Status:  Publisher    
Vitamin E comprises 8 functionally unique isoforms and may be a suitable candidate for the adjuvant treatment of prostate cancer. In this study, we examined the ability of 2 vitamin E isoforms [α-tocotrienol (γ-TT) and δ-tocotrienol (δ-TT)] and 4 synthetic derivatives [γ- and δ-tocotrienol succinate (γ-TS, δ-TS), α-tocopheryl polyethylene glycol succinate (TPGS), and α-tocopheryl polyethylene glycol ether (TPGS-e)] of vitamin E to induce cell death in AR- (DU145 and PC-3) and AR+ (LNCaP) prostate cancer cell lines. Our results show that δ-TT and TPGS-e are the most effective isoform and synthetic derivative, respectively, of all compounds examined. Overall, the results of our study suggest that isoforms and synthetic derivatives of vitamin E have the potency to trigger both caspase-dependent and -independent DNA damage and dominant caspase-independent programmed cell death. The capacity of vitamin E to trigger caspase-independent programmed cell death suggests that it may be useful in the chemotherapy of prostate cancer since it may prevent the tumor resistance commonly associated with the use of classical chemotherapeutic agents that trigger caspase-dependent programmed cell death.
C Constantinou; C M Neophytou; P Vraka; J A Hyatt; K A Papas; A I Constantinou
Related Documents :
11983028 - Retroviral transfer of the p16ink4a cdna inhibits c6 glioma formation in wistar rats.
12079428 - Diol- and triol-type ginseng saponins potentiate the apoptosis of nih3t3 cells exposed ...
18681848 - Deficiency in lysosomal enzyme secretion is associated with upregulation of phosphatidy...
6354748 - Reduction in p53 synthesis during differentiation of friend-erythroleukemia cells. corr...
23132928 - Delineating the core regulatory elements crucial for directed cell migration by examini...
18470918 - Flow-induced shear stresses increase the number of cell-cell contacts within extracellu...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-12-15
Journal Detail:
Title:  Nutrition and cancer     Volume:  -     ISSN:  1532-7914     ISO Abbreviation:  -     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7905040     Medline TA:  Nutr Cancer     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
a Yasoo Health, Ltd. , Nicosia , Cyprus.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Egyptian sweet marjoram leaves protect against genotoxicity, immunosuppression and other complicatio...
Next Document:  Individual differences in lexical processing at 18 months predict vocabulary growth in typically dev...