Document Detail


Induction of Caspase-9, Biochemical Assessment and Morphological Changes Caused by Apoptosis in Cancer Cells Treated with Goniothalamin Extracted from Goniothalamus macrophyllus.
MedLine Citation:
PMID:  24377517     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Goniothalamin, a natural compound extracted from Goniothalamus sp. belonging to the Annonacae family, possesses anticancer properties towards several tumor cell lines. This study focused on apoptosis induction by goniothalamin (GTN) in the Hela cervical cancer cell line. Cell growth inhibition was measured by MTT assay and the IC50 value of goniothalamin was 3.2±0.72 μg/ml. Morphological changes and biochemical processes associated with apoptosis were evident on phase contrast microscopy and fluorescence microscopy. DNA fragmentation, DNA damage, caspase-9 activation and a large increase in the sub-G1 and S cell cycle phases confirmed the occurrence of apoptosis in a time-dependent manner. It could be concluded that goniothalamin show a promising cytotoxicity effect against cervical cancer cells (Hela) and the cell death mode induced by goniothalamin was apoptosis.
Authors:
Aied Mohammed Alabsi; Rola Ali; Abdul Manaf Ali; Hazlan Harun; Sami Abdo Radman Al-Dubai; Kurubaran Ganasegeran; Mustafa Ahmed Alshagga; Sameer Dirhim Salem; Noor Hayaty Binti Abu Kasim
Related Documents :
23016607 - Effect of three different storage media on survival of periodontal ligament cells using...
23762407 - Mir-7 triggers cell cycle arrest at the g1/s transition by targeting multiple genes inc...
23284987 - Microparticle-mediated transfer of the viral receptors car and cd46, and the cftr chann...
24947867 - Organic anion transporting polypeptides and organic cation transporter 1 contribute to ...
7880167 - Stochastic resonance as a possible mechanism of amplification of weak electric signals ...
2420477 - Adipocyte differentiation of 3t3-l1 cells in serum-free hormone-supplemented media: eff...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Asian Pacific journal of cancer prevention : APJCP     Volume:  14     ISSN:  1513-7368     ISO Abbreviation:  Asian Pac. J. Cancer Prev.     Publication Date:  2013  
Date Detail:
Created Date:  2013-12-31     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101130625     Medline TA:  Asian Pac J Cancer Prev     Country:  Thailand    
Other Details:
Languages:  eng     Pagination:  6273-80     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Clinical Observation and Prognostic Analysis of Pemetrexed plus Platinum as First-line Treatment in ...
Next Document:  Screening of Differentially Expressed Genes among Various TNM Stages of Lung Adenocarcinoma by Genom...