Document Detail

Induction of Bacillus subtilis sporulation by nucleosides: inosine appears to be sporogen.
MedLine Citation:
PMID:  6780519     Owner:  NLM     Status:  MEDLINE    
Inosine completely reversed the selective inhibition of sporulation in Bacillus subtilis 168 caused bym-aminobenzeneboronic acid; guanosine and adenosine, but not xanthosine, partially reversed inhibition, whereas pyrimidine nucleosides were slightly effective. In addition, 0.005 to 0.025 mM inosine caused a four- to fivefold stimulation of sporulation of B. subtilis grown in minimal salts medium. Ultraviolet and infrared spectra and other physical and chemical properties of inosine were markedly similar to those of "sporogen," a previously described endogenous sporogenesis factor present in sporulating Bacillus species.
V Sekar; S P Wilson; J H Hageman
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of bacteriology     Volume:  145     ISSN:  0021-9193     ISO Abbreviation:  J. Bacteriol.     Publication Date:  1981 Jan 
Date Detail:
Created Date:  1981-04-24     Completed Date:  1981-04-24     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2985120R     Medline TA:  J Bacteriol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  489-93     Citation Subset:  IM    
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MeSH Terms
Adenine / pharmacology
Bacillus subtilis / drug effects,  physiology*
Boronic Acids / pharmacology
Hypoxanthines / pharmacology
Inosine / analysis,  pharmacology*
Nucleosides / pharmacology
Spores, Bacterial / physiology
Grant Support
Reg. No./Substance:
0/Boronic Acids; 0/Hypoxanthines; 0/Nucleosides; 30418-59-8/3-aminobenzeneboronic acid; 58-63-9/Inosine; 73-24-5/Adenine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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