| Inducible nitric oxide synthase activity in myocardium after myocardial infarction in rabbit. | |
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MedLine Citation:
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PMID: 7529019 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The activity of nitric oxide synthase (NOS) in infarcted and noninfarcted rabbit myocardium was determined. NOS activity, as measured by conversion of [14C]arginine to [14C]citrulline, was significantly higher in the infarcted area of myocardium (22.7 +/- 3.7 fmol/mg as compared to 7.67 +/- 1.0 in noninfarcted area). NOS activity within the area of risk remained on control level. Increased inducible NOS activity was observed on the first postoperative day and persisted for at least 14 days; it declined 3 weeks after infarction. Citrulline formation was inhibited by N-omega-nitro-L-arginine and N-omega-monomethyl-L-arginine The localization of NOS by monoclonal anti-NOS antibody indicates mononuclear cells/macrophages as the likely source of the enzyme. The concentrations of tumor necrosis factor-alpha and interleukin-1 beta were not increased in peripheral blood or myocardium. |
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Authors:
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R R Dudek; S Wildhirt; A Conforto; V Pinto; H Suzuki; S Winder; R J Bing |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biochemical and biophysical research communications Volume: 205 ISSN: 0006-291X ISO Abbreviation: Biochem. Biophys. Res. Commun. Publication Date: 1994 Dec |
Date Detail:
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Created Date: 1995-02-02 Completed Date: 1995-02-02 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372516 Medline TA: Biochem Biophys Res Commun Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1671-80 Citation Subset: IM |
Affiliation:
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Department of Experimental Cardiology, Huntington Medical Research Institutes, Pasadena, CA 91101. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Oxidoreductases
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biosynthesis* Animals Creatine Kinase / blood Enzyme Induction Immunohistochemistry Interleukin-1 / blood, metabolism Isoenzymes Leukocytes, Mononuclear / enzymology Macrophages / enzymology Male Myocardial Infarction / enzymology*, immunology Myocardium / enzymology*, immunology Nitric Oxide Synthase Rabbits Time Factors Tumor Necrosis Factor-alpha / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Interleukin-1; 0/Isoenzymes; 0/Tumor Necrosis Factor-alpha; EC 1.14.13.39/Nitric Oxide Synthase; EC 1.4.-/Amino Acid Oxidoreductases; EC 2.7.3.2/Creatine Kinase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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