Document Detail

Inducible clocks: living in an unpredictable world.
MedLine Citation:
PMID:  18419313     Owner:  NLM     Status:  MEDLINE    
All mammals have daily cycles of behavior (e.g., wake-sleep and feeding), and physiology (e.g., hormone secretion and body temperature). These cycles are typically entrained to the external light/dark cycle, but they can be altered dramatically under conditions of restricted food availability, changes in ambient temperature, or the presence of external stimuli such as predators. During the past 30 years, one of the best studied of these responses has been the entrainment of circadian rhythms to food availability. Experiments in rats and other rodents have provided evidence for a food-entrainable oscillator (FEO) in the mammalian circadian timing system (CTS). Until recently, however, very little was understood about the locus subserving the FEO or the functional interrelationship between the FEO and the master CTS pacemaker, the suprachiasmatic nucleus (SCN). We discuss here new data on the location of the FEO and suggest that it may involve an oscillator mechanism that is "induced" by starvation and refeeding.
C B Saper; P M Fuller
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Cold Spring Harbor symposia on quantitative biology     Volume:  72     ISSN:  0091-7451     ISO Abbreviation:  Cold Spring Harb. Symp. Quant. Biol.     Publication Date:  2007  
Date Detail:
Created Date:  2008-04-18     Completed Date:  2008-08-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1256107     Medline TA:  Cold Spring Harb Symp Quant Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  543-50     Citation Subset:  IM    
Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA.
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MeSH Terms
Afferent Pathways / physiology
Biological Clocks / genetics,  physiology*
Circadian Rhythm / genetics,  physiology
Dorsomedial Hypothalamic Nucleus / physiology
Eating / physiology
Efferent Pathways / physiology
Models, Neurological
Suprachiasmatic Nucleus / physiology

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