Document Detail

Inducible clindamycin resistance in Staphylococcus aureus isolated from clinical samples.
MedLine Citation:
PMID:  20404457     Owner:  NLM     Status:  MEDLINE    
PURPOSE: Clindamycin is commonly used in the treatment of erythromycin resistant Staphylococcus aureus causing skin and soft tissue infections. In vitro routine tests for clindamycin susceptibility may fail to detect inducible clindamycin resistance due to erm genes resulting in treatment failure, thus necessitating the need to detect such resistance by a simple D test on routine basis. MATERIALS AND METHOD: 247 Staphylococcus aureus isolates were subjected to routine antibiotic susceptibility testing including oxacillin (1ìg) by Kirby Bauer disc diffusion method. Inducible clindamycin resistance was detected by D test, as per CLSI guidelines on erythromycin resistant isolates. RESULTS: 36 (14.5%) isolates showed inducible clindamycin resistance, nine (3.6%) showed constitutive resistance while remaining 35 (14.1%) showed MS phenotype. Inducible resistance and MS phenotype were found to be higher in MRSA as compared to MSSA (27.6%, 24.3% and 1.6%, 4% respectively). CONCLUSION: Study showed that D test should be used as a mandatory method in routine disc diffusion testing to detect inducible clindamycin resistance.
V Deotale; D K Mendiratta; U Raut; P Narang
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Indian journal of medical microbiology     Volume:  28     ISSN:  1998-3646     ISO Abbreviation:  Indian J Med Microbiol     Publication Date:    2010 Apr-Jun
Date Detail:
Created Date:  2010-04-20     Completed Date:  2010-07-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8700903     Medline TA:  Indian J Med Microbiol     Country:  India    
Other Details:
Languages:  eng     Pagination:  124-6     Citation Subset:  IM    
Department of Microbiology, Mahatma Gandhi Institute of Medical Sciences, Sevagram. Dist Wardha, M.S. - 442 102, India.
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MeSH Terms
Anti-Bacterial Agents / pharmacology*
Clindamycin / pharmacology*
Drug Resistance, Bacterial*
Microbial Sensitivity Tests / methods
Staphylococcal Infections / microbiology*
Staphylococcus aureus / drug effects*,  isolation & purification*
Transcriptional Activation*
Reg. No./Substance:
0/Anti-Bacterial Agents; 18323-44-9/Clindamycin

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