| Induced sputum versus bronchoalveolar lavage during acute chest syndrome in sickle cell disease. | |
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MedLine Citation:
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PMID: 12969866 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Previous reports have shown that in more than 40% of adults with acute chest syndrome (ACS), fat droplets suggestive of pulmonary fat embolism were present in alveolar macrophages. To determine whether induced sputum (IS) is a reliable test for detecting this embolism, we compared bronchoalveolar lavage and IS results in 20 patients with ACS. We found a correlation between the number of Oil Red O-stained macrophages in sputum and lavage fluid (Spearman's coefficient: rho = 0.657, p < 0.018). Sputum cytology was then studied in another 60 patients who had sickle cell disease with ACS. An elevated percentage of Oil Red O-stained macrophages was found in the sputum of 37/47 patients, but they did not include any of the patients with sickle cell disease but no clinical symptoms. Patients suffering from ACS with Oil Red O-stained macrophages had more extrathoracic concomitant pain than those without (76 vs. 50%, p < 10-8), had more neurologic symptoms (7 vs. 0%, p < 10-8), a lower differential platelet count (-49 +/- 121 vs. +85 +/- 229, p < 0.04), and higher abnormal transaminase values (28 vs. 17%, p < 0.01). We conclude that IS analysis is a safe, noninvasive, and useful test for fat embolism detection in ACS. |
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Authors:
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Emmanuelle Lechapt; Anoosha Habibi; Dora Bachir; Frederic Galacteros; Annette Schaeffer; Dominique Desvaux; Laurent Brochard; Bruno Housset; Bertrand Godeau; Bernard Maitre |
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Publication Detail:
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Type: Comparative Study; Evaluation Studies; Journal Article Date: 2003-09-11 |
Journal Detail:
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Title: American journal of respiratory and critical care medicine Volume: 168 ISSN: 1073-449X ISO Abbreviation: Am. J. Respir. Crit. Care Med. Publication Date: 2003 Dec |
Date Detail:
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Created Date: 2003-12-03 Completed Date: 2004-01-08 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9421642 Medline TA: Am J Respir Crit Care Med Country: United States |
Other Details:
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Languages: eng Pagination: 1373-7 Citation Subset: AIM; IM |
Affiliation:
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Department of Pathology, Sickle Cell Disease Center, Hôpital Henri Mondor, Assistance Publique-Hôpitaux de Paris, Inserm U492, Université Paris XII, Créteil, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Adult Anemia, Sickle Cell / complications*, pathology Bronchoalveolar Lavage Fluid / cytology* Bronchoscopy Embolism, Fat / etiology, pathology* Female Humans Macrophages, Alveolar / pathology* Male Pulmonary Embolism / etiology, pathology* Reproducibility of Results Sputum / cytology* Syndrome |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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