Document Detail

Induced sputum nitrites correlate with FEV1 in children with cystic fibrosis.
MedLine Citation:
PMID:  20096026     Owner:  NLM     Status:  MEDLINE    
AIM: To determine the difference in the levels of nitrites in induced sputum of children with cystic fibrosis (CF) and controls. Furthermore, to evaluate the association between induced sputum nitrites and lung function in children with CF. METHODS: Nitrites, cell differentials, white blood cell count, were estimated in induced sputum of 20 children with CF and 10 age-matched healthy controls. Nitrites in induced sputum samples were measured using the Greiss assay. Lung function was ascertained by spirometry. RESULTS: We observed high levels of nitrites in CF (184.8 +/- 11.07 microM/L) versus controls (56.4 +/- 5.7 microM/L) (p < 0.01). A positive correlation between neturophil percent and nitrites, white blood cell count and nitrites (p < 0.05) in children with CF was observed. Sputum nitrites correlated negatively with FEV(1) (p < 0.05) in children with CF. CONCLUSION: Induced sputum nitrite could serve as a useful non invasive marker for assessing the degree of inflammation in the airways of children with CF.
N Anil; M Singh; A Rajwanshi; H Vohra
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Publication Detail:
Type:  Journal Article     Date:  2010-01-21
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992)     Volume:  99     ISSN:  1651-2227     ISO Abbreviation:  Acta Paediatr.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-05-24     Completed Date:  2010-07-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9205968     Medline TA:  Acta Paediatr     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  711-4     Citation Subset:  IM    
.Department of Experimental Medicine and Biotechnology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
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MeSH Terms
Biological Markers / analysis
Case-Control Studies
Cystic Fibrosis / pathology,  physiopathology*
Forced Expiratory Volume*
Leukocyte Count
Nitrites / analysis*
Sputum / chemistry*,  cytology
Vital Capacity
Reg. No./Substance:
0/Biological Markers; 0/Nitrites

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