| Induced sputum, exhaled breath condensate and nasal lavage fluid in electroplating workers exposed to chromium. | |
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MedLine Citation:
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PMID: 17291410 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Occupational exposure to chromium may cause airway inflammation and bronchial asthma. In this study we investigated the effect of chromium on the respiratory tract of exposed and non-exposed electroplating workers using spirometry and analysis of induced sputum (IS), exhaled breath condensate (EBC) and nasal lavage fluid (NLF). In both groups spirometry was normal; chromium in induced sputum was higher in exposed workers (7.90 +/- 0.855 microg/L, vs 1.78 +/- 0.075 microg/L; p<0.001); no significant difference was found in induced sputum cellularity. Median nitrite concentration in EBC was significantly higher in exposed subjects (4.35 micromol/L, 5 degrees -95 degrees percentile: 1.88-10.13 vs 0.11 micromol/L, 5-95 percentile: 0-0.72) (p<0.001). IL-6 and TNF-alpha were not detectable in EBC. Median IL-6 concentration in nasal lavage fluid was higher in exposed workers (5.72 pg/ml, 5-95 percentile: 0-65.25 pg/ml vs 0.28 pg/ml, 5-95 percentile: 0-1.7 pg/ml) (p<0.01). No differences in Eosinophil Cationic Protein concentration were found. TNF-alpha was not detectable in NLF. Chromium in induced sputum correlated with nitrites in EBC. For the first time three non-invasive methods were used to assess changes in respiratory tract in workers exposed to chromium. The results suggest chromium exerts an inflammatory/irritative action on airways. |
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Authors:
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N Murgia; G Muzi; M Dell' Omo; P Montuschi; D Melchiorri; G Ciabattoni; E P Abbritti; N Orazi; I E Sapia; G Abbritti |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: International journal of immunopathology and pharmacology Volume: 19 ISSN: 0394-6320 ISO Abbreviation: Int J Immunopathol Pharmacol Publication Date: 2006 Oct-Dec |
Date Detail:
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Created Date: 2007-02-12 Completed Date: 2007-11-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8911335 Medline TA: Int J Immunopathol Pharmacol Country: Italy |
Other Details:
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Languages: eng Pagination: 67-71 Citation Subset: IM |
Affiliation:
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Section of Occupational Medicine, Respiratory Diseases and Toxicology, University of Perugia, Perugia, Italy. nicola.murgia@med.unipg.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Breath Tests* Chromium / adverse effects* Electroplating* Humans Interleukin-6 / analysis Male Middle Aged Nasal Lavage Fluid / chemistry* Nitrites / analysis Occupational Exposure* Sputum / metabolism* Tumor Necrosis Factor-alpha / analysis |
| Chemical | |
Reg. No./Substance:
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0/Interleukin-6; 0/Nitrites; 0/Tumor Necrosis Factor-alpha; 7440-47-3/Chromium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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