Document Detail

Induced sputum, exhaled breath condensate and nasal lavage fluid in electroplating workers exposed to chromium.
MedLine Citation:
PMID:  17291410     Owner:  NLM     Status:  MEDLINE    
Occupational exposure to chromium may cause airway inflammation and bronchial asthma. In this study we investigated the effect of chromium on the respiratory tract of exposed and non-exposed electroplating workers using spirometry and analysis of induced sputum (IS), exhaled breath condensate (EBC) and nasal lavage fluid (NLF). In both groups spirometry was normal; chromium in induced sputum was higher in exposed workers (7.90 +/- 0.855 microg/L, vs 1.78 +/- 0.075 microg/L; p<0.001); no significant difference was found in induced sputum cellularity. Median nitrite concentration in EBC was significantly higher in exposed subjects (4.35 micromol/L, 5 degrees -95 degrees percentile: 1.88-10.13 vs 0.11 micromol/L, 5-95 percentile: 0-0.72) (p<0.001). IL-6 and TNF-alpha were not detectable in EBC. Median IL-6 concentration in nasal lavage fluid was higher in exposed workers (5.72 pg/ml, 5-95 percentile: 0-65.25 pg/ml vs 0.28 pg/ml, 5-95 percentile: 0-1.7 pg/ml) (p<0.01). No differences in Eosinophil Cationic Protein concentration were found. TNF-alpha was not detectable in NLF. Chromium in induced sputum correlated with nitrites in EBC. For the first time three non-invasive methods were used to assess changes in respiratory tract in workers exposed to chromium. The results suggest chromium exerts an inflammatory/irritative action on airways.
N Murgia; G Muzi; M Dell' Omo; P Montuschi; D Melchiorri; G Ciabattoni; E P Abbritti; N Orazi; I E Sapia; G Abbritti
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of immunopathology and pharmacology     Volume:  19     ISSN:  0394-6320     ISO Abbreviation:  Int J Immunopathol Pharmacol     Publication Date:    2006 Oct-Dec
Date Detail:
Created Date:  2007-02-12     Completed Date:  2007-11-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8911335     Medline TA:  Int J Immunopathol Pharmacol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  67-71     Citation Subset:  IM    
Section of Occupational Medicine, Respiratory Diseases and Toxicology, University of Perugia, Perugia, Italy.
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MeSH Terms
Breath Tests*
Chromium / adverse effects*
Interleukin-6 / analysis
Middle Aged
Nasal Lavage Fluid / chemistry*
Nitrites / analysis
Occupational Exposure*
Sputum / metabolism*
Tumor Necrosis Factor-alpha / analysis
Reg. No./Substance:
0/Interleukin-6; 0/Nitrites; 0/Tumor Necrosis Factor-alpha; 7440-47-3/Chromium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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