Document Detail


Induced sputum concentrations of mucin in patients with asthma and chronic cough.
MedLine Citation:
PMID:  20081098     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Mucus hypersecretion is an important pathophysiologic index of airway disease. Measurement of secreted mucin in sputum has been reported in asthma, but not in chronic cough with or without increased sputum production. METHODS: We studied 49 patients with classic asthma (CA), 39 with cough-variant asthma (CVA), nine and five with chronic cough associated with sinobronchial syndrome (SBS) and gastroesophageal reflux disease (GERD), respectively, and 11 healthy controls. Seventeen patients with CA, but none from the other groups, were taking antiinflammatory medications. Mucin levels in induced sputum supernatants were measured by enzyme-linked immunosorbent assay, which detects airway mucin, probably including MUC5AC and MUC5B. RESULTS: Mucin levels were higher in patients with CA (674.2 +/- 548.8 microg/mL) and SBS (638.4 +/- 650.7 microg/mL) than in controls (212.0 +/- 167.1 microg/mL) (P = .0037 and .044). They were also higher in patients with CA than in those with CVA (350.4 +/- 374.0 microg/mL) and GERD (134.3 +/- 93.1 microg/mL) (P = .0016 and 0.015), but results did not differ between the latter groups and controls. When the four disease groups were combined, patients with frequent sputum production had greater mucin levels than those with occasional (P = .0023) or no sputum production (P < .0001). Patients with CA showed negative correlations of mucin levels with respiratory resistance indices on impulse oscillation and with airway sensitivity to methacholine. CONCLUSIONS: Sputum mucin levels differ in various respiratory conditions when compared with controls, primarily reflecting the degree of sputum production. Airway mucin might possibly exert protective effects in asthma, at least between exacerbations, but this issue needs to be further clarified by future studies.
Authors:
Makiko Jinnai; Akio Niimi; Tetsuya Ueda; Hirofumi Matsuoka; Masaya Takemura; Masafumi Yamaguchi; Kojiro Otsuka; Tsuyoshi Oguma; Tomoshi Takeda; Isao Ito; Hisako Matsumoto; Michiaki Mishima
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Publication Detail:
Type:  Journal Article     Date:  2010-01-15
Journal Detail:
Title:  Chest     Volume:  137     ISSN:  1931-3543     ISO Abbreviation:  Chest     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-05-05     Completed Date:  2010-06-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1122-9     Citation Subset:  AIM; IM    
Affiliation:
Department of Respiratory Medicine, Kyoto University Graduate School of Medicine, Shogoin, Sakyoku, Kyoto 606-8507, Japan. niimi@kuhp.kyoto-u.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Analysis of Variance
Asthma / complications,  metabolism*,  physiopathology
Case-Control Studies
Chronic Disease
Cough / etiology,  metabolism*,  physiopathology
Cross-Sectional Studies
Female
Gastroesophageal Reflux / complications
Humans
Male
Middle Aged
Mucins / metabolism*
Reproducibility of Results
Respiratory Function Tests
Sputum / metabolism*
Chemical
Reg. No./Substance:
0/Mucins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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