Document Detail

Induced pulsation of a continuous-flow total artificial heart in a mock circulatory system.
MedLine Citation:
PMID:  20153967     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: We studied the hemodynamic effects of inducing an artificial pulse in a continuous-flow total artificial heart consisting of 2 axial-flow pumps in a mock circulatory system. METHODS: We varied the amplitude (maximum minus minimum speed), beat rate and systolic duration of the left pump, right pump or both. Mean left and right pump speeds were maintained at 11 and 8 krpm, respectively. Flow rates and arterial and filling pressures were measured in the systemic and pulmonary portions of the mock circulation. Pulse pressure, pulse flow, pulsatility index and surplus hemodynamic energy (SHE) were calculated. The percent change in mean left atrial pressure (LAP) during each induced pulsatility condition was compared with that observed during continuous flow. RESULTS: Systemic pulse pressures of 17 to 61 mm Hg were attained when the left pump was pulsed, regardless of right pump pulsatility settings. The pulse pressure was directly related to the systolic duration and inversely related to the left pump beat rate. SHE ranged from 0.1 to 3.0 mm Hg, and its changes were comparable to those in pulse pressure. The LAP was reduced by left pump pulsation, but a maximal reduction (<or=77%) relative to continuous flow was achieved when the two pumps were copulsed or counterpulsed at a slow rate (10 bpm). CONCLUSIONS: This approach provided maximal flow pulsatility and an adequate reduction in LAP, which may be elevated in recipients of a cardiac replacement device. Further bench and in vivo experiments are needed to assess pump synchronization modes.
Hassan A Khalil; Daniel T Kerr; Mark A Schusterman; William E Cohn; O H Frazier; Branislav Radovancevic
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2010-02-13
Journal Detail:
Title:  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation     Volume:  29     ISSN:  1557-3117     ISO Abbreviation:  J. Heart Lung Transplant.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-04-12     Completed Date:  2010-07-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9102703     Medline TA:  J Heart Lung Transplant     Country:  United States    
Other Details:
Languages:  eng     Pagination:  568-73     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2010 International Society for Heart and Lung Transplantation. Published by Elsevier Inc. All rights reserved.
Cardiovascular Surgical Research Laboratories, Texas Heart Institute at St Luke's Episcopal Hospital, Houston, Texas 77225-0345, USA.
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MeSH Terms
Blood Pressure / physiology
Heart, Artificial*
Hemodynamics / physiology*
Models, Cardiovascular*
Prosthesis Design
Pulmonary Circulation / physiology
Pulsatile Flow / physiology*
Vascular Resistance / physiology
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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