Document Detail

Induced pluripotent stem cells generate both retinal ganglion cells and photoreceptors: therapeutic implications in degenerative changes in glaucoma and age-related macular degeneration.
MedLine Citation:
PMID:  20166150     Owner:  NLM     Status:  MEDLINE    
The direct reprogramming of somatic cells to a pluripotent state holds significant implications for treating intractable degenerative diseases by ex vivo cell therapy. In addition, the reprogrammed cells can serve as a model for diseases and the discovery of drugs and genes. Here, we demonstrate that mouse fibroblast induced pluripotent stem cells (iPSCs) represent a renewable and robust source of retinal progenitors, capable of generating a wide range of retinal cell types that includes retinal ganglion cells (RGCs), cone, and rod photoreceptors. They respond to simulated microenvironment of early and late retinal histogenesis by differentiating into stage-specific retinal cell types through the recruitment of normal mechanisms. The depth of the retinal potential of iPSCs suggests that they may be used to formulate stem cell approaches to understand and treat a wide range of retinal degenerative diseases from glaucoma to age-related macular degeneration (AMD).
Sowmya Parameswaran; Sudha Balasubramanian; Norbert Babai; Fang Qiu; James D Eudy; Wallace B Thoreson; Iqbal Ahmad
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Stem cells (Dayton, Ohio)     Volume:  28     ISSN:  1549-4918     ISO Abbreviation:  Stem Cells     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-21     Completed Date:  2010-06-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9304532     Medline TA:  Stem Cells     Country:  United States    
Other Details:
Languages:  eng     Pagination:  695-703     Citation Subset:  IM    
Department of Ophthalmology and Visual Sciences, Omaha, Nebraska, USA.
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MeSH Terms
Cell Differentiation*
Cell Line
Cell Lineage
Gene Expression Regulation
Glaucoma / therapy*
Induced Pluripotent Stem Cells / cytology*,  metabolism
Macular Degeneration / therapy*
Photoreceptor Cells / cytology*,  metabolism
Retinal Ganglion Cells / cytology*,  metabolism

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