Document Detail


Induced pluripotent stem cell-derived cardiomyocytes in studies of inherited arrhythmias.
MedLine Citation:
PMID:  23281414     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The discovery of the genetic basis of inherited arrhythmias has paved the way for an improved understanding of arrhythmogenesis in a wide spectrum of life-threatening conditions. In vitro expression of mutations and transgenic animal models have been instrumental in enhancing this understanding, but the applicability of results to the human heart remains unknown. The ability to differentiate induced pluripotent stem cells (iPSs) into cardiomyocytes enables the potential to generate patient-specific myocytes, which could be used to recapitulate the features of inherited arrhythmias in the context of the patient's genetic background. Few studies have been reported on iPS-derived myocytes obtained from patients with heritable arrhythmias, but they have demonstrated the applicability of this innovative approach to the study of inherited arrhythmias. Here we review the results achieved by iPS investigations in arrhythmogenic syndromes and discuss the existing challenges to be addressed before the use of iPS-derived myocytes can become a part of personalized management of inherited arrhythmias.
Authors:
Silvia G Priori; Carlo Napolitano; Elisa Di Pasquale; Gianluigi Condorelli
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2013-01-02
Journal Detail:
Title:  The Journal of clinical investigation     Volume:  123     ISSN:  1558-8238     ISO Abbreviation:  J. Clin. Invest.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-02     Completed Date:  2013-03-11     Revised Date:  2014-03-19    
Medline Journal Info:
Nlm Unique ID:  7802877     Medline TA:  J Clin Invest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  84-91     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Genetically Modified
Arrhythmias, Cardiac / genetics,  therapy*
Cell Differentiation*
Genetic Diseases, Inborn / genetics,  therapy*
Humans
Induced Pluripotent Stem Cells*
Myocytes, Cardiac / transplantation*
Grant Support
ID/Acronym/Agency:
GGP11141//Telethon
Comments/Corrections

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