| Induced human gestational hypoprolactinemia: lack of action on fetal adrenal androgen synthesis. | |
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MedLine Citation:
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PMID: 6448263 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To investigate the possible role of PRL in the control of fetal adrenal function, blood samples were collected from maternal peripheral and cord blood from six women at delivery, who had received treatment with bromocriptine (3.75--35 mg daily) for the entire gestation. A group of eight untreated parturients served as control. Parameters measured were PRL and dehydroepiandrosterone, the latter as an indicator of fetal adrenal function. PRL was significantly suppressed (P < 0.002), whereas dehydroepiandrosterone was not influenced by bromocriptine treatment. The results indicate that the control of fetal production of androgenic substrate by the adrenals is not specifically PRL dependent. |
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Authors:
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E del Pozo; M Bigazzi; J Calaf |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of clinical endocrinology and metabolism Volume: 51 ISSN: 0021-972X ISO Abbreviation: J. Clin. Endocrinol. Metab. Publication Date: 1980 Oct |
Date Detail:
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Created Date: 1980-12-16 Completed Date: 1980-12-16 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0375362 Medline TA: J Clin Endocrinol Metab Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 936-8 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenal Glands
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embryology*,
physiology Adult Bromocriptine / therapeutic use Dehydroepiandrosterone / blood* Female Fetal Blood / metabolism Humans Maternal-Fetal Exchange Pregnancy* Prolactin / blood* |
| Chemical | |
Reg. No./Substance:
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25614-03-3/Bromocriptine; 53-43-0/Dehydroepiandrosterone; 9002-62-4/Prolactin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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