Document Detail

Induced color blindness in goldfish: a behavioral and electrophysiological study.
MedLine Citation:
PMID:  1843759     Owner:  NLM     Status:  MEDLINE    
To answer the question whether, like man, ethambutol treated fish would become color-blind, wavelength discrimination was measured behaviorally in goldfish, preceding, during and after ethambutol treatment. The results are that of the three high discrimination abilities at around 400, 500 and 600 nm, ethambutol affected the latter one. Red-green discrimination is lost reversibly leaving the discriminations in the blue-green and violet range unaffected. This red-green discrimination deficiency cannot be accounted for by a loss of long wavelength cones since the ERG and luminosity functions remain unaffected. Intracellular horizontal cell recordings in goldfish show that ethambutol hyperpolarizes all three types of cone driven horizontal cells and changes their color coding such that their spectral characteristics become cone-like as is the case in dark adapted retina. So, the initial effect induced by ethambutol seems to be an adaptation deficiency in color vision related tasks. Human wavelength discrimination and increment threshold spectral sensitivity functions obtained at low luminance levels are compared to behavioral functions in ethambutol treated goldfish. The high similarity between the ethambutol effects in man and goldfish, and the effects observed in the horizontal cell responses in goldfish are highly indicative that horizontal cells play a key role in color vision. So far their function has been puzzling.
H Spekreijse; J J Wietsma; C Neumeyer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Vision research     Volume:  31     ISSN:  0042-6989     ISO Abbreviation:  Vision Res.     Publication Date:  1991  
Date Detail:
Created Date:  1993-03-12     Completed Date:  1993-03-12     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0417402     Medline TA:  Vision Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  551-62     Citation Subset:  IM    
The Netherlands Ophthalmic Research Institute, Amsterdam.
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MeSH Terms
Color Perception / physiology*
Color Vision Defects / chemically induced,  physiopathology*
Disease Models, Animal
Neurons / physiology
Photoreceptor Cells / physiopathology
Sensory Thresholds
Reg. No./Substance:

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