Document Detail

Induced brain hypothermia in asphyxiated human newborn infants: a retrospective chart analysis of physiological and adverse effects.
MedLine Citation:
PMID:  10551967     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To assess the physiological effects and adverse side-effects of induced hypothermia in asphyxiated newborn infants as a base for future controlled, randomized trials. DESIGN: Retrospective chart analysis with historical controls. SETTING: Tertiary neonatal intensive care unit of the University of Cape Town, South Africa. PATIENTS: Twenty-one asphyxiated newborns treated with induced hypothermia between September 1997 and February 1998 were compared to 15 asphyxiated newborn infants admitted during March to August 1997. The two groups of infants did not differ in patient characteristics or severity of asphyxia (comparison group vs hypothermia group: Apgar at 5 min 5.3 +/- 3.1 vs 5.2 +/- 2.3; base deficit 15.6 +/- 6.3 vs 11.5 +/- 7.2 and Thompson neurological score 10.1 +/- 4.0 vs 9.1 +/- 3.6). INTERVENTIONS: Hypothermia was induced by placing a cap formed from coolpacks, at a temperature of about 10 degrees C, around the head of asphyxiated newborn infants to maintain the nasopharyngeal temperature between 34 and 35 degrees C. Hypothermia was maintained for 3 days. MEASUREMENTS AND RESULTS: In the comparison group 4/15 infants died and in the hypothermia group 4/21 died. Hypothermia was induced at a median of 6.0 h (range 45 min to 53 h) post-partum, maintained for an average of 80 h (median 77.5 h, range 22 to 185 h) and resulted in an average nasopharyngeal temperature of 34.6 +/- 0.5 degrees C. Hypothermia reduced abdominal skin temperature from 36.3 +/- 0.5 degrees C to 35.1 +/- 0.35 degrees C (p = 0.0001), heart rate from 139 +/- 21 to 121 +/- 13 beats/min (p < 0.0001) and respiratory rate from 67 +/- 11 to 56 +/- 9 breaths/min (p = 0.005). Neither episodes of bradycardia nor dysrhythmias, apnea, clinical signs of bleeding diathesis in the hypothermia group nor differences in the frequency of hypoglycaemia and urinary output, blood in urine or tracheal secretion between the two groups were observed. In the survivors the neurological score, assessed at day 2 and day 5, fell from 10.9 +/- 3.5 to 8.1 +/- 4.5 in the hypothermia group and rose from 8.1 +/- 2. 5 to 9.0 +/- 3.1 in the comparison group (p = 0.003). CONCLUSIONS: Adverse effects of mild hypothermia induced for 3 days in asphyxiated newborns were significantly less than expected from previous reports on neonates with accidental hypothermia.
G Simbruner; C Haberl; V Harrison; L Linley; A E Willeitner
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Intensive care medicine     Volume:  25     ISSN:  0342-4642     ISO Abbreviation:  Intensive Care Med     Publication Date:  1999 Oct 
Date Detail:
Created Date:  2000-01-05     Completed Date:  2000-01-05     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7704851     Medline TA:  Intensive Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1111-7     Citation Subset:  IM    
Division of Neonatology, University Children's Clinic, Ludwig-Maximilians University, Lindwurmstrasse 4, D-80 337 Munich, Germany.
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MeSH Terms
Apgar Score
Asphyxia Neonatorum / metabolism,  mortality,  physiopathology,  therapy*
Birth Weight
Blood Gas Analysis
Body Temperature
Brain* / metabolism,  physiopathology
Gestational Age
Heart Rate
Hypothermia, Induced / adverse effects*,  methods*
Infant, Newborn
Monitoring, Physiologic
Neurologic Examination
Retrospective Studies
Survival Analysis
Time Factors
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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