Document Detail


Induced abdominal compartment syndrome increases intracranial pressure in neurotrauma patients: a prospective study.
MedLine Citation:
PMID:  11445709     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To evaluate the effect of a stepwise increase in intra-abdominal pressure (IAP) on intracranial pressure (ICP) and to further define the pressure transmission characteristics of different body compartments. DESIGN: A prospective, nonrandomized study. SETTING: A multidisciplinary intensive care unit at a university medical center. PATIENTS: Fifteen patients with moderate-to-severe head injury. INTERVENTIONS: All patients were studied after the initial stabilization and resolution of intracranial hypertension. Measurements were carried out before and 20 mins after IAP was increased by positioning a soft, 15-L water bag on the patient's abdomen. MEASUREMENTS AND MAIN RESULTS: Placing weights upon the abdomen generated a significant increase in IAP, which rose from 4.7 +/- 2.9 to 15.5 +/- 4.1 mm Hg (p <.001). The rise in IAP caused concomitant and rapid increases in central venous pressure (from 6.2 +/- 2.4 to 10.4 +/- 2.9 mm Hg; p <.001), internal jugular pressure (from 11.9 +/- 3.2 to 14.3 +/- 2.4 mm Hg; p <.001), and ICP (from 12.0 +/- 4.2 to 15.5 +/- 4.4 mm Hg; p <.001). Thoracic transmural pressure, calculated as the difference between central venous pressure and esophageal pressure, remained constant during the protocol. Respiratory system compliance decreased from 58.9 +/- 9.8 to 44.9 +/- 9.4 mL/cm H2O (p <.001) in all patients because of decreased chest wall compliance. The mean arterial pressure increased from 94 +/- 11 to 100 +/- 13 mm Hg (p <.01), which allowed the maintenance of a stable cerebral perfusion pressure (82.4 +/- 10.3 vs. 84.7 +/- 11.5 mm Hg; p = NS) despite the ICP increase. CONCLUSIONS: Increased IAP causes a significant rise in ICP in head trauma patients. This effect seems to be the result of an increase in intrathoracic pressure, which causes a functional obstruction to cerebral venous outflow. Routine assessment of IAP may help clinicians to identify remediable causes of increased ICP. Caution should be used when applying laparoscopic techniques in neurotrauma patients.
Authors:
G Citerio; E Vascotto; F Villa; S Celotti; A Pesenti
Related Documents :
14971569 - Rotatory nystagmus synchronous with heartbeat: a treatable form of nystagmus.
897999 - Experimental extracranial-intracranial anastomosis.
3760039 - Role of a hydrostatic pressure gradient in the formation of early ischemic brain edema.
12483059 - Reduction of cerebral infarction using the third circulation.
6808809 - Intracranial hypertension and brain oedema in albino rabbits. part 3: effect of acute s...
20812789 - Noninvasive monitoring of cerebrovascular reactivity with near infrared spectroscopy in...
24880819 - Urinary angiotensinogen and urinary sodium are associated with blood pressure in normoa...
10678599 - Kyphoscoliosis ventilatory insufficiency: noninvasive management outcomes.
15157569 - The influence of nonylphenol on life-history of the earthworm dendrobaena octaedra savi...
Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Critical care medicine     Volume:  29     ISSN:  0090-3493     ISO Abbreviation:  Crit. Care Med.     Publication Date:  2001 Jul 
Date Detail:
Created Date:  2001-07-10     Completed Date:  2001-08-09     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0355501     Medline TA:  Crit Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1466-71     Citation Subset:  AIM; IM    
Affiliation:
Dipartimento di Anestesia e Rianimazione, Nuovo Ospedale San Gerardo, Monza, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Abdomen*
Adolescent
Adult
Brain Injuries / physiopathology*
Compartment Syndromes / physiopathology*
Humans
Intensive Care Units
Intracranial Pressure*
Linear Models
Male
Middle Aged
Prospective Studies
Respiratory Mechanics
Comments/Corrections
Comment In:
Crit Care Med. 2002 Sep;30(9):2170   [PMID:  12352073 ]
Crit Care Med. 2002 Oct;30(10):2402-3; author reply 2403   [PMID:  12394989 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Maternal magnesium sulfate treatment is associated with reduced brain-blood flow perfusion in preter...
Next Document:  Sepsis and evolution of the innate immune response.