Document Detail


Induced IL-17-producing invariant NKT cells require activation in presence of TGF-β and IL-1β.
MedLine Citation:
PMID:  23293359     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
IL-17 production by innate-like lymphocytes, including γδ and invariant NKT (iNKT) cells, have been ascribed to specific lineages that are endowed with this functional specialization during thymic differentiation. IL-17-producing iNKT cells have been described as a CD4(-)NK1.1(-) lineage in mice and CD161(+) in humans. We found that, in mice, noncommitted iNKT cells can be induced to produce IL-17 when activated in presence of TGF-β and IL-1β. This peripheral induction of IL-17 expression could be observed in any subset irrespectively of CD4 and NK1.1 expression, the process leading to loss of NK1.1 expression and partial CD4 downmodulation. Furthermore, induced IL-17-producing iNKT cells were sufficient to drive neutrophilic airways inflammation upon intratracheal adoptive cell transfer into congenic mice. Taken together, our data show that similarly to regulatory T cells, which have a natural and peripherally induced subset, IL-17 production by iNKT cells can also be imprinted in natural iNKT17 cells or peripherally induced.
Authors:
Marta Monteiro; Catarina F Almeida; Ana Agua-Doce; Luis Graca
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of immunology (Baltimore, Md. : 1950)     Volume:  190     ISSN:  1550-6606     ISO Abbreviation:  J. Immunol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-07     Completed Date:  2013-03-14     Revised Date:  2013-07-29    
Medline Journal Info:
Nlm Unique ID:  2985117R     Medline TA:  J Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  805-11     Citation Subset:  AIM; IM    
Affiliation:
Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, 1649-025 Lisbon, Portugal.
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MeSH Terms
Descriptor/Qualifier:
Animals
CD4-Positive T-Lymphocytes / drug effects,  immunology,  metabolism
Inflammation / immunology,  metabolism
Interleukin-17 / biosynthesis*
Interleukin-1beta / pharmacology*
Interleukin-6 / pharmacology
Lymphocyte Activation / drug effects*,  immunology*
Mice
Natural Killer T-Cells / drug effects*,  immunology*,  metabolism
Neuropilin-1 / metabolism
Neutrophils / immunology
Respiratory System / immunology
T-Lymphocyte Subsets / drug effects,  immunology,  metabolism
Transforming Growth Factor beta / pharmacology*
Chemical
Reg. No./Substance:
0/Interleukin-17; 0/Interleukin-1beta; 0/Interleukin-6; 0/Transforming Growth Factor beta; 144713-63-3/Neuropilin-1
Comments/Corrections
Comment In:
J Immunol. 2013 Jun 15;190(12):5910-1   [PMID:  23749965 ]
J Immunol. 2013 Jun 15;190(12):5909-10   [PMID:  23749964 ]

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