Document Detail

Induced IL-17-producing invariant NKT cells require activation in presence of TGF-β and IL-1β.
MedLine Citation:
PMID:  23293359     Owner:  NLM     Status:  MEDLINE    
IL-17 production by innate-like lymphocytes, including γδ and invariant NKT (iNKT) cells, have been ascribed to specific lineages that are endowed with this functional specialization during thymic differentiation. IL-17-producing iNKT cells have been described as a CD4(-)NK1.1(-) lineage in mice and CD161(+) in humans. We found that, in mice, noncommitted iNKT cells can be induced to produce IL-17 when activated in presence of TGF-β and IL-1β. This peripheral induction of IL-17 expression could be observed in any subset irrespectively of CD4 and NK1.1 expression, the process leading to loss of NK1.1 expression and partial CD4 downmodulation. Furthermore, induced IL-17-producing iNKT cells were sufficient to drive neutrophilic airways inflammation upon intratracheal adoptive cell transfer into congenic mice. Taken together, our data show that similarly to regulatory T cells, which have a natural and peripherally induced subset, IL-17 production by iNKT cells can also be imprinted in natural iNKT17 cells or peripherally induced.
Marta Monteiro; Catarina F Almeida; Ana Agua-Doce; Luis Graca
Related Documents :
23802069 - Icos is associated with poor prognosis in breast cancer as it promotes the amplificatio...
24890519 - Th17 cells and il-17 increase with poor prognosis in patients with acute myeloid leukemia.
23806269 - An hla-modified ovarian cancer cell line induced ctl responses specific to an epitope d...
23114599 - The nf-κb regulator malt1 determines the encephalitogenic potential of th17 cells.
23733539 - Quantitative evaluation of stem cell grafting in the central nervous system of mice by ...
23568529 - Kynurenine 3-monooxygenase mediates inhibition of th17 differentiation via catabolism o...
16706229 - The capacity of mesenchymal stem cells for neural differentiation in vitro.
6976809 - Human leukemia cell line k562 responds to erythroid-potentiating activity.
7500989 - Do human lymphocytes exposed to the fallout of the chernobyl accident exhibit an adapti...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of immunology (Baltimore, Md. : 1950)     Volume:  190     ISSN:  1550-6606     ISO Abbreviation:  J. Immunol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-07     Completed Date:  2013-03-14     Revised Date:  2013-07-29    
Medline Journal Info:
Nlm Unique ID:  2985117R     Medline TA:  J Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  805-11     Citation Subset:  AIM; IM    
Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, 1649-025 Lisbon, Portugal.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
CD4-Positive T-Lymphocytes / drug effects,  immunology,  metabolism
Inflammation / immunology,  metabolism
Interleukin-17 / biosynthesis*
Interleukin-1beta / pharmacology*
Interleukin-6 / pharmacology
Lymphocyte Activation / drug effects*,  immunology*
Natural Killer T-Cells / drug effects*,  immunology*,  metabolism
Neuropilin-1 / metabolism
Neutrophils / immunology
Respiratory System / immunology
T-Lymphocyte Subsets / drug effects,  immunology,  metabolism
Transforming Growth Factor beta / pharmacology*
Reg. No./Substance:
0/Interleukin-17; 0/Interleukin-1beta; 0/Interleukin-6; 0/Transforming Growth Factor beta; 144713-63-3/Neuropilin-1
Comment In:
J Immunol. 2013 Jun 15;190(12):5910-1   [PMID:  23749965 ]
J Immunol. 2013 Jun 15;190(12):5909-10   [PMID:  23749964 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  A general approach for controlling transcription and probing epigenetic mechanisms: application to t...
Next Document:  Longitudinal changes in CD4(+) T-cell memory responses induced by BCG vaccination of newborns.